Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis

Implications for pursuit eye tracking

Rebekka Lencer, Sarah K. Keedy, James L. Reilly, Bruce E. McDonough, Margret S H Harris, Andreas Sprenger, John A. Sweeney

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Visual motion processing and its use for pursuit eye movement control represent a valuable model for studying the use of sensory input for action planning. In psychotic disorders, alterations of visual motion perception have been suggested to cause pursuit eye tracking deficits. We evaluated this system in functional neuroimaging studies of untreated first-episode schizophrenia (N= 24), psychotic bipolar disorder patients (N= 13) and healthy controls (N= 20). During a passive visual motion processing task, both patient groups showed reduced activation in the posterior parietal projection fields of motion-sensitive extrastriate area V5, but not in V5 itself. This suggests reduced bottom-up transfer of visual motion information from extrastriate cortex to perceptual systems in parietal association cortex. During active pursuit, activation was enhanced in anterior intraparietal sulcus and insula in both patient groups, and in dorsolateral prefrontal cortex and dorsomedial thalamus in schizophrenia patients. This may result from increased demands on sensorimotor systems for pursuit control due to the limited availability of perceptual motion information about target speed and tracking error. Visual motion information transfer deficits to higher-level association cortex may contribute to well-established pursuit tracking abnormalities, and perhaps to a wider array of alterations in perception and action planning in psychotic disorders.

Original languageEnglish (US)
Pages (from-to)30-38
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume194
Issue number1
DOIs
StatePublished - Oct 31 2011

Fingerprint

Parietal Lobe
Psychotic Disorders
Schizophrenia
Motion Perception
Functional Neuroimaging
Visual Perception
Visual Cortex
Eye Movements
Prefrontal Cortex
Thalamus
Bipolar Disorder

Keywords

  • Action planning
  • Extraretinal systems
  • Functional imaging
  • Psychotic bipolar disorder
  • Schizophrenia
  • Sensory processing

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis : Implications for pursuit eye tracking. / Lencer, Rebekka; Keedy, Sarah K.; Reilly, James L.; McDonough, Bruce E.; Harris, Margret S H; Sprenger, Andreas; Sweeney, John A.

In: Psychiatry Research - Neuroimaging, Vol. 194, No. 1, 31.10.2011, p. 30-38.

Research output: Contribution to journalArticle

Lencer, Rebekka ; Keedy, Sarah K. ; Reilly, James L. ; McDonough, Bruce E. ; Harris, Margret S H ; Sprenger, Andreas ; Sweeney, John A. / Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis : Implications for pursuit eye tracking. In: Psychiatry Research - Neuroimaging. 2011 ; Vol. 194, No. 1. pp. 30-38.
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