TY - JOUR
T1 - Alternative Agents in Refractory Chronic Urticaria
T2 - Evidence and Considerations on Their Selection and Use
AU - Khan, David A.
PY - 2013/9
Y1 - 2013/9
N2 - Patients with chronic urticaria (CU) who are refractory to antihistamines are frequently encountered by allergy specialists. Several alternative agents have been used to treat these patients; however, the evidence to support these agents is generally limited. This review focuses on some of the more commonly used alternative agents in refractory CU, including anti-inflammatory agents (montelukast, hydroxychloroquine, dapsone, sulfasalazine, methotrexate, colchicine), immunosuppressants (cyclosporine, tacrolimus, mycophenolate), and immunomodulatory agents (omalizumab, immune globulin). The evidence to support their use, dosing, potential toxicity, monitoring, and selection of these alternative agents is reviewed. Although numerous knowledge gaps exist for alternative agents in refractory CU, a rational, patient-based approach can be used with a goal of improving control and quality of life and minimizing adverse medication effects.
AB - Patients with chronic urticaria (CU) who are refractory to antihistamines are frequently encountered by allergy specialists. Several alternative agents have been used to treat these patients; however, the evidence to support these agents is generally limited. This review focuses on some of the more commonly used alternative agents in refractory CU, including anti-inflammatory agents (montelukast, hydroxychloroquine, dapsone, sulfasalazine, methotrexate, colchicine), immunosuppressants (cyclosporine, tacrolimus, mycophenolate), and immunomodulatory agents (omalizumab, immune globulin). The evidence to support their use, dosing, potential toxicity, monitoring, and selection of these alternative agents is reviewed. Although numerous knowledge gaps exist for alternative agents in refractory CU, a rational, patient-based approach can be used with a goal of improving control and quality of life and minimizing adverse medication effects.
KW - Alternative agent
KW - Anti-inflammatory
KW - Chronic
KW - Immunomodulatory
KW - Immunosuppressant
KW - Refractory
KW - Urticaria
UR - http://www.scopus.com/inward/record.url?scp=84883461501&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883461501&partnerID=8YFLogxK
U2 - 10.1016/j.jaip.2013.06.003
DO - 10.1016/j.jaip.2013.06.003
M3 - Article
C2 - 24565613
AN - SCOPUS:84883461501
SN - 2213-2198
VL - 1
SP - 433-440.e1
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 5
ER -