Alternative splicing produces transcripts encoding two forms of the α subunit of GTP-binding protein G(o)

Michael Strathmann, Thomas M. Wilkie, Melvin I. Simon

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

The α subunit of the guanine nucleotide-binding protein G(o) ('o' for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of G(o) α subunit were isolated from a mouse brain library. These two forms, which we call G(o)Aα and G(o)Bα, appear to be products of alternative splicing. G(o)Aα differs from G(o)Bα over the C-terminal third of the deduced protein sequence. Both forms are predicted to be substrates for ADP-ribosylation by pertussis toxin. G(o)Aα transcripts are present in a variety of tissues but are most abundant in brain. The G(o)Bα transcript is expressed at highest levels in brain and testis. It is possible G(o)Aα and G(o)Bα have different functions.

Original languageEnglish (US)
Pages (from-to)6477-6481
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number17
DOIs
StatePublished - 1990

Keywords

  • guanine nucleotide-binding protein
  • signal transduction

ASJC Scopus subject areas

  • General

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