Alternative splicing regulation of telomerase: A new paradigm?

Mandy S. Wong, Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Alternative splicing affects approximately 95% of eukaryotic genes, greatly expanding the coding capacity of complex genomes. Although our understanding of alternative splicing has increased rapidly, current knowledge of splicing regulation has largely been derived from studies of highly expressed mRNAs. Telomerase is a key example of a protein that is alternatively spliced, but it is expressed at very low levels and although it is known that misregulation of telomerase splicing is a hallmark of nearly all cancers, the details of this process are unclear. Here we review work showing that hTERT expression is in part regulated by atypical alternative splicing, perhaps due to its exceptionally low expression level. We propose that these differential regulatory mechanisms may be widely applicable to other genes and may provide new opportunities for the development of cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)430-438
Number of pages9
JournalTrends in Genetics
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Cancer therapy
  • Low-abundance transcript
  • RNA splicing
  • Regulation
  • Telomere

ASJC Scopus subject areas

  • Genetics

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