Alzheimer's disease and down syndrome rodent models exhibit audiogenic seizures

Cara J. Westmark, Pamela R. Westmark, James S. Malter

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Amyloid-β protein precursor (AβPP) is overexpressed in Alzheimer's disease (AD), Down syndrome (DS), autism, and fragile X syndrome. Seizures are a common phenotype in all of these neurological disorders, yet the underlying molecular mechanism(s) of seizure induction and propagation remain largely unknown. We demonstrate that AD (Tg2576) and DS (Ts65Dn) mice exhibit audiogenic seizures, which can be attenuated with antagonists to metabotropic glutamate receptor 5 (mGluR5) or by passive immunization with anti-amyloid-β antibody. Our data strongly implicates AβPP or a catabolite in seizure susceptibility and suggests that mGluR5 mediates this response.

Original languageEnglish (US)
Pages (from-to)1009-1013
Number of pages5
JournalJournal of Alzheimer's Disease
Volume20
Issue number4
DOIs
StatePublished - 2010

Fingerprint

Down Syndrome
Rodentia
Alzheimer Disease
Seizures
Metabotropic Glutamate 5 Receptor
Amyloid beta-Protein Precursor
Fragile X Syndrome
Passive Immunization
Autistic Disorder
Nervous System Diseases
Amyloid
Anti-Idiotypic Antibodies
Phenotype

Keywords

  • Alzheimer's disease
  • amyloid-β
  • amyloid-β protein precursor
  • audiogenic seizure
  • Down syndrome
  • metabotropic glutamate receptor 5

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology
  • Medicine(all)

Cite this

Alzheimer's disease and down syndrome rodent models exhibit audiogenic seizures. / Westmark, Cara J.; Westmark, Pamela R.; Malter, James S.

In: Journal of Alzheimer's Disease, Vol. 20, No. 4, 2010, p. 1009-1013.

Research output: Contribution to journalArticle

Westmark, Cara J. ; Westmark, Pamela R. ; Malter, James S. / Alzheimer's disease and down syndrome rodent models exhibit audiogenic seizures. In: Journal of Alzheimer's Disease. 2010 ; Vol. 20, No. 4. pp. 1009-1013.
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