Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults

Takashi Tarumi, Binu P. Thomas, Ciwen Wang, Li Zhang, Jie Liu, Marcel Turner, Jonathan Riley, Nikita Tangella, Kyle B. Womack, Diana R. Kerwin, C. Munro Cullum, Hanzhang Lu, Wanpen Vongpatanasin, David C. Zhu, Rong Zhang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ambulatory blood pressure (ABP) reflects the end-organ vascular stress in daily life; however, its influence on brain neuronal fiber integrity and cerebral blood flow (CBF) remains unclear. The objective of this study was to determine the associations among ABP, white matter (WM) neuronal fiber integrity, and CBF in older adults. We tested 144 participants via ABP monitoring and diffusion tensor imaging. The total level and pulsatile indices of CBF were measured by phase-contrast MRI and transcranial Doppler, respectively. Neuropsychological assessment was conducted in 72 participants. Among ambulatory and office BP measures, elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD). Furthermore, these associations remained significant after adjusting for age, antihypertensive use, aortic stiffness, WM lesion volume, and office PP. Radial diffusivity (RD) was elevated in the regions with decreased FA, while axial diffusivity was unaltered. The reduction in diastolic index explained a significant proportion of the individual variability in FA, MD, and RD. Executive function performance was correlated with WM fiber integrity. These findings suggest that elevated ambulatory PP may deteriorate brain neuronal fiber integrity via reduction in diastolic index.

Original languageEnglish (US)
JournalJournal of Cerebral Blood Flow and Metabolism
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Cerebrovascular Circulation
Blood Pressure
Anisotropy
Brain
Ambulatory Blood Pressure Monitoring
Vascular Stiffness
Diffusion Tensor Imaging
Executive Function
Skeleton
Antihypertensive Agents
Blood Vessels
White Matter

Keywords

  • Aging
  • cerebral blood flow
  • cognitive impairment/decline
  • hypertension
  • white matter disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults. / Tarumi, Takashi; Thomas, Binu P.; Wang, Ciwen; Zhang, Li; Liu, Jie; Turner, Marcel; Riley, Jonathan; Tangella, Nikita; Womack, Kyle B.; Kerwin, Diana R.; Cullum, C. Munro; Lu, Hanzhang; Vongpatanasin, Wanpen; Zhu, David C.; Zhang, Rong.

In: Journal of Cerebral Blood Flow and Metabolism, 01.01.2017.

Research output: Contribution to journalArticle

@article{a4611c1cdc2248beb4ed65b080113683,
title = "Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults",
abstract = "Ambulatory blood pressure (ABP) reflects the end-organ vascular stress in daily life; however, its influence on brain neuronal fiber integrity and cerebral blood flow (CBF) remains unclear. The objective of this study was to determine the associations among ABP, white matter (WM) neuronal fiber integrity, and CBF in older adults. We tested 144 participants via ABP monitoring and diffusion tensor imaging. The total level and pulsatile indices of CBF were measured by phase-contrast MRI and transcranial Doppler, respectively. Neuropsychological assessment was conducted in 72 participants. Among ambulatory and office BP measures, elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD). Furthermore, these associations remained significant after adjusting for age, antihypertensive use, aortic stiffness, WM lesion volume, and office PP. Radial diffusivity (RD) was elevated in the regions with decreased FA, while axial diffusivity was unaltered. The reduction in diastolic index explained a significant proportion of the individual variability in FA, MD, and RD. Executive function performance was correlated with WM fiber integrity. These findings suggest that elevated ambulatory PP may deteriorate brain neuronal fiber integrity via reduction in diastolic index.",
keywords = "Aging, cerebral blood flow, cognitive impairment/decline, hypertension, white matter disease",
author = "Takashi Tarumi and Thomas, {Binu P.} and Ciwen Wang and Li Zhang and Jie Liu and Marcel Turner and Jonathan Riley and Nikita Tangella and Womack, {Kyle B.} and Kerwin, {Diana R.} and Cullum, {C. Munro} and Hanzhang Lu and Wanpen Vongpatanasin and Zhu, {David C.} and Rong Zhang",
year = "2017",
month = "1",
day = "1",
doi = "10.1177/0271678X17745027",
language = "English (US)",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults

AU - Tarumi, Takashi

AU - Thomas, Binu P.

AU - Wang, Ciwen

AU - Zhang, Li

AU - Liu, Jie

AU - Turner, Marcel

AU - Riley, Jonathan

AU - Tangella, Nikita

AU - Womack, Kyle B.

AU - Kerwin, Diana R.

AU - Cullum, C. Munro

AU - Lu, Hanzhang

AU - Vongpatanasin, Wanpen

AU - Zhu, David C.

AU - Zhang, Rong

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Ambulatory blood pressure (ABP) reflects the end-organ vascular stress in daily life; however, its influence on brain neuronal fiber integrity and cerebral blood flow (CBF) remains unclear. The objective of this study was to determine the associations among ABP, white matter (WM) neuronal fiber integrity, and CBF in older adults. We tested 144 participants via ABP monitoring and diffusion tensor imaging. The total level and pulsatile indices of CBF were measured by phase-contrast MRI and transcranial Doppler, respectively. Neuropsychological assessment was conducted in 72 participants. Among ambulatory and office BP measures, elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD). Furthermore, these associations remained significant after adjusting for age, antihypertensive use, aortic stiffness, WM lesion volume, and office PP. Radial diffusivity (RD) was elevated in the regions with decreased FA, while axial diffusivity was unaltered. The reduction in diastolic index explained a significant proportion of the individual variability in FA, MD, and RD. Executive function performance was correlated with WM fiber integrity. These findings suggest that elevated ambulatory PP may deteriorate brain neuronal fiber integrity via reduction in diastolic index.

AB - Ambulatory blood pressure (ABP) reflects the end-organ vascular stress in daily life; however, its influence on brain neuronal fiber integrity and cerebral blood flow (CBF) remains unclear. The objective of this study was to determine the associations among ABP, white matter (WM) neuronal fiber integrity, and CBF in older adults. We tested 144 participants via ABP monitoring and diffusion tensor imaging. The total level and pulsatile indices of CBF were measured by phase-contrast MRI and transcranial Doppler, respectively. Neuropsychological assessment was conducted in 72 participants. Among ambulatory and office BP measures, elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD). Furthermore, these associations remained significant after adjusting for age, antihypertensive use, aortic stiffness, WM lesion volume, and office PP. Radial diffusivity (RD) was elevated in the regions with decreased FA, while axial diffusivity was unaltered. The reduction in diastolic index explained a significant proportion of the individual variability in FA, MD, and RD. Executive function performance was correlated with WM fiber integrity. These findings suggest that elevated ambulatory PP may deteriorate brain neuronal fiber integrity via reduction in diastolic index.

KW - Aging

KW - cerebral blood flow

KW - cognitive impairment/decline

KW - hypertension

KW - white matter disease

UR - http://www.scopus.com/inward/record.url?scp=85044380321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044380321&partnerID=8YFLogxK

U2 - 10.1177/0271678X17745027

DO - 10.1177/0271678X17745027

M3 - Article

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

ER -