Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique

Osamu Togao, Akio Hiwatashi, Jochen Keupp, Koji Yamashita, Kazufumi Kikuchi, Takashi Yoshiura, Masami Yoneyama, Marijn J. Kruiskamp, Koji Sagiyama, Masaya Takahashi, Hiroshi Honda

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In this study, we evaluated the dependence of saturation pulse length on APT imaging of diffuse gliomas using a parallel transmission-based technique. Twenty-two patients with diffuse gliomas (9 low-grade gliomas, LGGs, and 13 high-grade gliomas, HGGs) were included in the study. APT imaging was conducted at 3T with a 2-channel parallel transmission scheme using three different saturation pulse lengths (0.5 s, 1.0 s, 2.0 s). The 2D fast spin-echo sequence was used for imaging. Z-spectrum was obtained at 25 frequency off-sets from -6 to +6 ppm (step 0.5 ppm). A point-by-point B0 correction was performed with a B0 map. Magnetization transfer ratio (MTRasym) and ΔMTRasym (contrast between tumor and normal white matter) at 3.5 ppm were compared among different saturation lengths. A significant increase in MTRasym (3.5 ppm) of HGG was found when the length of saturation pulse became longer (3.09 ± 0.54% at 0.5 s, 3.83 ± 0.67% at 1 s, 4.12 ± 0.97% at 2 s), but MTRasym (3.5 ppm) was not different among the saturation lengths in LGG. ΔMTRasym (3.5 ppm) increased with the length of saturation pulse in both LGG (0.48 ± 0.56% at 0.5 s, 1.28 ± 0.56% at 1 s, 1.88 ± 0.56% at 2 s and HGG (1.72 ± 0.54% at 0.5 s, 2.90 ± 0.49% at 1 s, 3.83 ± 0.88% at 2 s). In both LGG and HGG, APT-weighted contrast was enhanced with the use of longer saturation pulses.

Original languageEnglish (US)
Article numbere0155925
JournalPLoS One
Volume11
Issue number5
DOIs
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique'. Together they form a unique fingerprint.

  • Cite this

    Togao, O., Hiwatashi, A., Keupp, J., Yamashita, K., Kikuchi, K., Yoshiura, T., Yoneyama, M., Kruiskamp, M. J., Sagiyama, K., Takahashi, M., & Honda, H. (2016). Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique. PLoS One, 11(5), [e0155925]. https://doi.org/10.1371/journal.pone.0155925