Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique

Osamu Togao, Akio Hiwatashi, Jochen Keupp, Koji Yamashita, Kazufumi Kikuchi, Takashi Yoshiura, Masami Yoneyama, Marijn J. Kruiskamp, Koji Sagiyama, Masaya Takahashi, Hiroshi Honda

Research output: Contribution to journalArticle

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Abstract

In this study, we evaluated the dependence of saturation pulse length on APT imaging of diffuse gliomas using a parallel transmission-based technique. Twenty-two patients with diffuse gliomas (9 low-grade gliomas, LGGs, and 13 high-grade gliomas, HGGs) were included in the study. APT imaging was conducted at 3T with a 2-channel parallel transmission scheme using three different saturation pulse lengths (0.5 s, 1.0 s, 2.0 s). The 2D fast spin-echo sequence was used for imaging. Z-spectrum was obtained at 25 frequency off-sets from -6 to +6 ppm (step 0.5 ppm). A point-by-point B0 correction was performed with a B0 map. Magnetization transfer ratio (MTRasym) and ΔMTRasym (contrast between tumor and normal white matter) at 3.5 ppm were compared among different saturation lengths. A significant increase in MTRasym (3.5 ppm) of HGG was found when the length of saturation pulse became longer (3.09 ± 0.54% at 0.5 s, 3.83 ± 0.67% at 1 s, 4.12 ± 0.97% at 2 s), but MTRasym (3.5 ppm) was not different among the saturation lengths in LGG. ΔMTRasym (3.5 ppm) increased with the length of saturation pulse in both LGG (0.48 ± 0.56% at 0.5 s, 1.28 ± 0.56% at 1 s, 1.88 ± 0.56% at 2 s and HGG (1.72 ± 0.54% at 0.5 s, 2.90 ± 0.49% at 1 s, 3.83 ± 0.88% at 2 s). In both LGG and HGG, APT-weighted contrast was enhanced with the use of longer saturation pulses.

Original languageEnglish (US)
Article numbere0155925
JournalPLoS One
Volume11
Issue number5
DOIs
StatePublished - May 1 2016

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Proton transfer
amides
Amides
Glioma
protons
Protons
image analysis
Imaging techniques
Tumors
Magnetization
methodology
APT
Neoplasms
neoplasms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Togao, O., Hiwatashi, A., Keupp, J., Yamashita, K., Kikuchi, K., Yoshiura, T., ... Honda, H. (2016). Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique. PLoS One, 11(5), [e0155925]. https://doi.org/10.1371/journal.pone.0155925

Amide proton transfer imaging of diffuse gliomas : Effect of saturation pulse length in parallel transmission-based technique. / Togao, Osamu; Hiwatashi, Akio; Keupp, Jochen; Yamashita, Koji; Kikuchi, Kazufumi; Yoshiura, Takashi; Yoneyama, Masami; Kruiskamp, Marijn J.; Sagiyama, Koji; Takahashi, Masaya; Honda, Hiroshi.

In: PLoS One, Vol. 11, No. 5, e0155925, 01.05.2016.

Research output: Contribution to journalArticle

Togao, O, Hiwatashi, A, Keupp, J, Yamashita, K, Kikuchi, K, Yoshiura, T, Yoneyama, M, Kruiskamp, MJ, Sagiyama, K, Takahashi, M & Honda, H 2016, 'Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique', PLoS One, vol. 11, no. 5, e0155925. https://doi.org/10.1371/journal.pone.0155925
Togao, Osamu ; Hiwatashi, Akio ; Keupp, Jochen ; Yamashita, Koji ; Kikuchi, Kazufumi ; Yoshiura, Takashi ; Yoneyama, Masami ; Kruiskamp, Marijn J. ; Sagiyama, Koji ; Takahashi, Masaya ; Honda, Hiroshi. / Amide proton transfer imaging of diffuse gliomas : Effect of saturation pulse length in parallel transmission-based technique. In: PLoS One. 2016 ; Vol. 11, No. 5.
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abstract = "In this study, we evaluated the dependence of saturation pulse length on APT imaging of diffuse gliomas using a parallel transmission-based technique. Twenty-two patients with diffuse gliomas (9 low-grade gliomas, LGGs, and 13 high-grade gliomas, HGGs) were included in the study. APT imaging was conducted at 3T with a 2-channel parallel transmission scheme using three different saturation pulse lengths (0.5 s, 1.0 s, 2.0 s). The 2D fast spin-echo sequence was used for imaging. Z-spectrum was obtained at 25 frequency off-sets from -6 to +6 ppm (step 0.5 ppm). A point-by-point B0 correction was performed with a B0 map. Magnetization transfer ratio (MTRasym) and ΔMTRasym (contrast between tumor and normal white matter) at 3.5 ppm were compared among different saturation lengths. A significant increase in MTRasym (3.5 ppm) of HGG was found when the length of saturation pulse became longer (3.09 ± 0.54{\%} at 0.5 s, 3.83 ± 0.67{\%} at 1 s, 4.12 ± 0.97{\%} at 2 s), but MTRasym (3.5 ppm) was not different among the saturation lengths in LGG. ΔMTRasym (3.5 ppm) increased with the length of saturation pulse in both LGG (0.48 ± 0.56{\%} at 0.5 s, 1.28 ± 0.56{\%} at 1 s, 1.88 ± 0.56{\%} at 2 s and HGG (1.72 ± 0.54{\%} at 0.5 s, 2.90 ± 0.49{\%} at 1 s, 3.83 ± 0.88{\%} at 2 s). In both LGG and HGG, APT-weighted contrast was enhanced with the use of longer saturation pulses.",
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