Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Wei Peng, Jenna L. Jewell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1. Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

Original languageEnglish (US)
Pages (from-to)R89-R91
JournalCurrent Biology
Volume30
Issue number2
DOIs
StatePublished - Jan 20 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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