Amino acid signalling upstream of mTOR

Jenna L. Jewell, Ryan C. Russell, Kun Liang Guan

Research output: Contribution to journalArticle

436 Scopus citations

Abstract

Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that is part of mTOR complex 1 (mTORC1), a master regulator that couples amino acid availability to cell growth and autophagy. Multiple cues modulate mTORC1 activity, such as growth factors, stress, energy status and amino acids. Although amino acids are key environmental stimuli, exactly how they are sensed and how they activate mTORC1 is not fully understood. Recently, a model has emerged whereby mTORC1 activation occurs at the lysosome and is mediated through an amino acid sensing cascade involving RAG GTPases, Ragulator and vacuolar H+-ATPase (v-ATPase).

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2013

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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