AMP-activated protein kinase regulation and biological actions in the heart

Vlad G. Zaha, Lawrence H. Young

Research output: Contribution to journalReview article

154 Scopus citations

Abstract

AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart.

Original languageEnglish (US)
Pages (from-to)800-814
Number of pages15
JournalCirculation research
Volume111
Issue number6
DOIs
StatePublished - Aug 31 2012

Keywords

  • cardiac metabolism
  • cardioprotection
  • heart failure
  • myocardial ischemia
  • protein kinases

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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