AMP-activated protein kinase regulation and biological actions in the heart

Vlad G. Zaha; Lawrence H. Young

doi:10.1161/CIRCRESAHA.111.255505

AMP-activated protein kinase regulation and biological actions in the heart

Vlad G. Zaha, Lawrence H. Young

Research output: Contribution to journal › Review article › peer-review

226 Scopus citations

Abstract

AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart.

Original language	English (US)
Pages (from-to)	800-814
Number of pages	15
Journal	Circulation research
Volume	111
Issue number	6
DOIs	https://doi.org/10.1161/CIRCRESAHA.111.255505
State	Published - Aug 31 2012

Keywords

cardiac metabolism
cardioprotection
heart failure
myocardial ischemia
protein kinases

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/CIRCRESAHA.111.255505

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abstract = "AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart.",

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AB - AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart.

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KW - cardioprotection

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KW - protein kinases

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AMP-activated protein kinase regulation and biological actions in the heart

Abstract

Keywords

ASJC Scopus subject areas

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