Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke

D. Walker-Batson, J. Mehta, P. Smith, M. Johnson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume64
DOIs
StatePublished - Jan 4 2016

Fingerprint

Aphasia
Amphetamine
Stroke
Pharmacology
Dextroamphetamine
Street Drugs
Drug Combinations
Language
Rehabilitation
Animal Models
Learning
Drug Therapy
Therapeutics
Pharmaceutical Preparations

Keywords

  • Amphetamine
  • Aphasia
  • Clinical trials
  • Neuromodulation
  • Stroke rehabilitation

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke. / Walker-Batson, D.; Mehta, J.; Smith, P.; Johnson, M.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 64, 04.01.2016, p. 225-230.

Research output: Contribution to journalArticle

@article{807d55142d80475cb58b60f95502e426,
title = "Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke",
abstract = "Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH.",
keywords = "Amphetamine, Aphasia, Clinical trials, Neuromodulation, Stroke rehabilitation",
author = "D. Walker-Batson and J. Mehta and P. Smith and M. Johnson",
year = "2016",
month = "1",
day = "4",
doi = "10.1016/j.pnpbp.2015.04.002",
language = "English (US)",
volume = "64",
pages = "225--230",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke

AU - Walker-Batson, D.

AU - Mehta, J.

AU - Smith, P.

AU - Johnson, M.

PY - 2016/1/4

Y1 - 2016/1/4

N2 - Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH.

AB - Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH.

KW - Amphetamine

KW - Aphasia

KW - Clinical trials

KW - Neuromodulation

KW - Stroke rehabilitation

UR - http://www.scopus.com/inward/record.url?scp=84946162073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946162073&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2015.04.002

DO - 10.1016/j.pnpbp.2015.04.002

M3 - Article

VL - 64

SP - 225

EP - 230

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

ER -