Amphotericin B tolerance: A characteristic of Candida parapsilosis not shared by other Candida species

S. M. Seidenfeld, B. H. Cooper, J. W. Smith, J. P. Luby, P. A. Mackowiak

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Thirty yeast isolates from clinical specimens were tested for their susceptibility to amphotericin B at 30 C, 37 C, and 39 C. Of the six Candida albicans, five Candida tropicalis, one Candida guilliermondii, one Candida krusei, one Candida pseudotropicalis, two Torulopsis glabrata, and four Cryptococcus neoformans isolates tested, all were inhibited at amphotericin B concentrations of ≤0.4 μg/ml and killed by concentrations of amphotericin B that were ≤16-fold higher than the minimal inhibitory concentration (MIC). Although growth of Candida parapsilosis was also inhibited by concentrations of amphotericin B of ≤0.4 μg/ml, minimal fungicidal concentrations of amphotericin B were ≥32-fold higher than MICs for each of the 10 isolates examined. This unique susceptibility pattern of C. parapsilosis resembles the antibiotic tolerance observed with Staphylococcus aureus. Variations in temperature within the experimental range did not affect the amphotericin B susceptibility for any of the yeasts examined.

Original languageEnglish (US)
Pages (from-to)116-119
Number of pages4
JournalJournal of Infectious Diseases
Volume147
Issue number1
StatePublished - 1983

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Amphotericin B
Candida
Yeasts
Candida tropicalis
Candida glabrata
Cryptococcus neoformans
Candida albicans
Staphylococcus aureus
Anti-Bacterial Agents
Temperature
Growth

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Amphotericin B tolerance : A characteristic of Candida parapsilosis not shared by other Candida species. / Seidenfeld, S. M.; Cooper, B. H.; Smith, J. W.; Luby, J. P.; Mackowiak, P. A.

In: Journal of Infectious Diseases, Vol. 147, No. 1, 1983, p. 116-119.

Research output: Contribution to journalArticle

Seidenfeld, SM, Cooper, BH, Smith, JW, Luby, JP & Mackowiak, PA 1983, 'Amphotericin B tolerance: A characteristic of Candida parapsilosis not shared by other Candida species', Journal of Infectious Diseases, vol. 147, no. 1, pp. 116-119.
Seidenfeld, S. M. ; Cooper, B. H. ; Smith, J. W. ; Luby, J. P. ; Mackowiak, P. A. / Amphotericin B tolerance : A characteristic of Candida parapsilosis not shared by other Candida species. In: Journal of Infectious Diseases. 1983 ; Vol. 147, No. 1. pp. 116-119.
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