Amplification of Adipogenic Commitment by VSTM2A

Blandine Secco; Étienne Camiré; Marc Antoine Brière; Alexandre Caron; Armande Billong; Yves Gélinas; Anne Marie Lemay; Kevin M. Tharp; Peter L. Lee; Stéphane Gobeil; Jean V. Guimond; Natacha Patey; David A. Guertin; Andreas Stahl; Élie Haddad; David Marsolais; Yohan Bossé; Kivanc Birsoy; Mathieu Laplante

doi:10.1016/j.celrep.2016.12.015

Amplification of Adipogenic Commitment by VSTM2A

Blandine Secco, Étienne Camiré, Marc Antoine Brière, Alexandre Caron, Armande Billong, Yves Gélinas, Anne Marie Lemay, Kevin M. Tharp, Peter L. Lee, Stéphane Gobeil, Jean V. Guimond, Natacha Patey, David A. Guertin, Andreas Stahl, Élie Haddad, David Marsolais, Yohan Bossé, Kivanc Birsoy, Mathieu Laplante

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface markers of adipocyte progenitors. Overexpression of VSTM2A induces adipogenesis, whereas its depletion impairs this process. VSTM2A controls preadipocyte determination at least in part by modulating BMP signaling and PPARγ2 activation. We propose a model in which VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.

Original language	English (US)
Pages (from-to)	93-106
Number of pages	14
Journal	Cell Reports
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2016.12.015
State	Published - Jan 3 2017
Externally published	Yes

Keywords

3T3-L1
adipogenesis
adipogenic commitment
adipose tissue
cell differentiation
cell signaling
obesity
preadipocyte

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2016.12.015

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Secco, B., Camiré, É., Brière, M. A., Caron, A., Billong, A., Gélinas, Y., Lemay, A. M., Tharp, K. M., Lee, P. L., Gobeil, S., Guimond, J. V., Patey, N., Guertin, D. A., Stahl, A., Haddad, É., Marsolais, D., Bossé, Y., Birsoy, K., & Laplante, M. (2017). Amplification of Adipogenic Commitment by VSTM2A. Cell Reports, 18(1), 93-106. https://doi.org/10.1016/j.celrep.2016.12.015

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abstract = "Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface markers of adipocyte progenitors. Overexpression of VSTM2A induces adipogenesis, whereas its depletion impairs this process. VSTM2A controls preadipocyte determination at least in part by modulating BMP signaling and PPARγ2 activation. We propose a model in which VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.",

keywords = "3T3-L1, adipogenesis, adipogenic commitment, adipose tissue, cell differentiation, cell signaling, obesity, preadipocyte",

author = "Blandine Secco and {\'E}tienne Camir{\'e} and Bri{\`e}re, {Marc Antoine} and Alexandre Caron and Armande Billong and Yves G{\'e}linas and Lemay, {Anne Marie} and Tharp, {Kevin M.} and Lee, {Peter L.} and St{\'e}phane Gobeil and Guimond, {Jean V.} and Natacha Patey and Guertin, {David A.} and Andreas Stahl and {\'E}lie Haddad and David Marsolais and Yohan Boss{\'e} and Kivanc Birsoy and Mathieu Laplante",

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AU - Secco, Blandine

AU - Camiré, Étienne

AU - Brière, Marc Antoine

AU - Caron, Alexandre

AU - Billong, Armande

AU - Gélinas, Yves

AU - Lemay, Anne Marie

AU - Tharp, Kevin M.

AU - Lee, Peter L.

AU - Gobeil, Stéphane

AU - Guimond, Jean V.

AU - Patey, Natacha

AU - Guertin, David A.

AU - Stahl, Andreas

AU - Haddad, Élie

AU - Marsolais, David

AU - Bossé, Yohan

AU - Birsoy, Kivanc

AU - Laplante, Mathieu

PY - 2017/1/3

Y1 - 2017/1/3

N2 - Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface markers of adipocyte progenitors. Overexpression of VSTM2A induces adipogenesis, whereas its depletion impairs this process. VSTM2A controls preadipocyte determination at least in part by modulating BMP signaling and PPARγ2 activation. We propose a model in which VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.

AB - Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface markers of adipocyte progenitors. Overexpression of VSTM2A induces adipogenesis, whereas its depletion impairs this process. VSTM2A controls preadipocyte determination at least in part by modulating BMP signaling and PPARγ2 activation. We propose a model in which VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.

KW - 3T3-L1

KW - adipogenesis

KW - adipogenic commitment

KW - adipose tissue

KW - cell differentiation

KW - cell signaling

KW - obesity

KW - preadipocyte

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ER -

Amplification of Adipogenic Commitment by VSTM2A

Abstract

Keywords

ASJC Scopus subject areas

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