Amplification of Adipogenic Commitment by VSTM2A

Blandine Secco, Étienne Camiré, Marc Antoine Brière, Alexandre Caron, Armande Billong, Yves Gélinas, Anne Marie Lemay, Kevin M. Tharp, Peter L. Lee, Stéphane Gobeil, Jean V. Guimond, Natacha Patey, David A. Guertin, Andreas Stahl, Élie Haddad, David Marsolais, Yohan Bossé, Kivanc Birsoy, Mathieu Laplante

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface markers of adipocyte progenitors. Overexpression of VSTM2A induces adipogenesis, whereas its depletion impairs this process. VSTM2A controls preadipocyte determination at least in part by modulating BMP signaling and PPARγ2 activation. We propose a model in which VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.

Original languageEnglish (US)
Pages (from-to)93-106
Number of pages14
JournalCell Reports
Volume18
Issue number1
DOIs
StatePublished - Jan 3 2017
Externally publishedYes

Keywords

  • 3T3-L1
  • adipogenesis
  • adipogenic commitment
  • adipose tissue
  • cell differentiation
  • cell signaling
  • obesity
  • preadipocyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Secco, B., Camiré, É., Brière, M. A., Caron, A., Billong, A., Gélinas, Y., Lemay, A. M., Tharp, K. M., Lee, P. L., Gobeil, S., Guimond, J. V., Patey, N., Guertin, D. A., Stahl, A., Haddad, É., Marsolais, D., Bossé, Y., Birsoy, K., & Laplante, M. (2017). Amplification of Adipogenic Commitment by VSTM2A. Cell Reports, 18(1), 93-106. https://doi.org/10.1016/j.celrep.2016.12.015