Amplification of Cyclin Genes in Colorectal Carcinoma

Fredrick S. Leach; Stephen J. Elledge; Charles J. Sherr; James K V Willson; Sanford Markowitz; Kenneth W. Kinzler; Bert Vogelstein

Amplification of Cyclin Genes in Colorectal Carcinoma

Fredrick S. Leach, Stephen J. Elledge, Charles J. Sherr, James K V Willson, Sanford Markowitz, Kenneth W. Kinzler, Bert Vogelstein

Simmons Comprehensive Cancer Center

Research output: Contribution to journal › Article › peer-review

213 Scopus citations

Abstract

The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin Dl, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.

Original language	English (US)
Pages (from-to)	1986-1989
Number of pages	4
Journal	Cancer research
Volume	53
Issue number	9
State	Published - May 1993

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

@article{94062b3332214dd38085a94df459de43,

title = "Amplification of Cyclin Genes in Colorectal Carcinoma",

abstract = "The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin Dl, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.",

author = "Leach, {Fredrick S.} and Elledge, {Stephen J.} and Sherr, {Charles J.} and Willson, {James K V} and Sanford Markowitz and Kinzler, {Kenneth W.} and Bert Vogelstein",

year = "1993",

month = may,

language = "English (US)",

volume = "53",

pages = "1986--1989",

journal = "Cancer research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "9",

}

TY - JOUR

T1 - Amplification of Cyclin Genes in Colorectal Carcinoma

AU - Leach, Fredrick S.

AU - Elledge, Stephen J.

AU - Sherr, Charles J.

AU - Willson, James K V

AU - Markowitz, Sanford

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

PY - 1993/5

Y1 - 1993/5

N2 - The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin Dl, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.

AB - The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin Dl, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.

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UR - http://www.scopus.com/inward/citedby.url?scp=0027273790&partnerID=8YFLogxK

M3 - Article

C2 - 8481900

AN - SCOPUS:0027273790

SN - 0008-5472

VL - 53

SP - 1986

EP - 1989

JO - Cancer research

JF - Cancer research

IS - 9

ER -

Amplification of Cyclin Genes in Colorectal Carcinoma

Abstract

ASJC Scopus subject areas

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