Amplification of cyclin genes in colorectal carcinomas

Fredrick S. Leach, Stephen J. Elledge, Charles J. Sherr, James K V Willson, Sanford Markowitz, Kenneth W. Kinzler, Bert Vogelstein

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms.

Original languageEnglish (US)
Pages (from-to)1986-1989
Number of pages4
JournalCancer Research
Volume53
Issue number9
StatePublished - May 1 1993

Fingerprint

Cyclins
Gene Amplification
Cyclin D2
Colorectal Neoplasms
Cyclin E
Genes
Cyclin D1
Neoplasms
Carcinogenesis
Breast Neoplasms
Cell Line
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Leach, F. S., Elledge, S. J., Sherr, C. J., Willson, J. K. V., Markowitz, S., Kinzler, K. W., & Vogelstein, B. (1993). Amplification of cyclin genes in colorectal carcinomas. Cancer Research, 53(9), 1986-1989.

Amplification of cyclin genes in colorectal carcinomas. / Leach, Fredrick S.; Elledge, Stephen J.; Sherr, Charles J.; Willson, James K V; Markowitz, Sanford; Kinzler, Kenneth W.; Vogelstein, Bert.

In: Cancer Research, Vol. 53, No. 9, 01.05.1993, p. 1986-1989.

Research output: Contribution to journalArticle

Leach, FS, Elledge, SJ, Sherr, CJ, Willson, JKV, Markowitz, S, Kinzler, KW & Vogelstein, B 1993, 'Amplification of cyclin genes in colorectal carcinomas', Cancer Research, vol. 53, no. 9, pp. 1986-1989.
Leach FS, Elledge SJ, Sherr CJ, Willson JKV, Markowitz S, Kinzler KW et al. Amplification of cyclin genes in colorectal carcinomas. Cancer Research. 1993 May 1;53(9):1986-1989.
Leach, Fredrick S. ; Elledge, Stephen J. ; Sherr, Charles J. ; Willson, James K V ; Markowitz, Sanford ; Kinzler, Kenneth W. ; Vogelstein, Bert. / Amplification of cyclin genes in colorectal carcinomas. In: Cancer Research. 1993 ; Vol. 53, No. 9. pp. 1986-1989.
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