Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Research output: Contribution to journalArticle

Abstract

A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

Original languageEnglish (US)
Pages (from-to)368-370
Number of pages3
JournalMolecular cell
Volume79
Issue number3
DOIs
StatePublished - Aug 6 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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