Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Milan R. Savani; Kalil G. Abdullah; Samuel K. McBrayer

doi:10.1016/j.molcel.2020.07.014

Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Milan R. Savani, Kalil G. Abdullah, Samuel K. McBrayer

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

Original language	English (US)
Pages (from-to)	368-370
Number of pages	3
Journal	Molecular cell
Volume	79
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.07.014
State	Published - Aug 6 2020

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1016/j.molcel.2020.07.014

Cite this

@article{74cdb0b58fa944ee80ec81467de3ad1b,

title = "Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage",

abstract = "A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.",

author = "Savani, {Milan R.} and Abdullah, {Kalil G.} and McBrayer, {Samuel K.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

day = "6",

doi = "10.1016/j.molcel.2020.07.014",

language = "English (US)",

volume = "79",

pages = "368--370",

journal = "Molecular cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Amplifying the Noise

T2 - Oncometabolites Mask an Epigenetic Signal of DNA Damage

AU - Savani, Milan R.

AU - Abdullah, Kalil G.

AU - McBrayer, Samuel K.

PY - 2020/8/6

Y1 - 2020/8/6

N2 - A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

AB - A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

UR - http://www.scopus.com/inward/record.url?scp=85088856096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85088856096&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2020.07.014

DO - 10.1016/j.molcel.2020.07.014

M3 - Comment/debate

C2 - 32763225

AN - SCOPUS:85088856096

SN - 1097-2765

VL - 79

SP - 368

EP - 370

JO - Molecular cell

JF - Molecular cell

IS - 3

ER -

Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this