Amyloid-beta peptides are cytotoxic to oligodendrocytes.

J. Xu, S. Chen, S. H. Ahmed, H. Chen, G. Ku, M. P. Goldberg, C. Y. Hsu

Research output: Contribution to journalArticle

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Amyloid-beta peptide (Abeta), a 39-43 amino acid peptide derived from beta-amyloid precursor protein, forms insoluble fibrillar aggregates that have been linked to neuronal and vascular degeneration in AD and cerebral amyloid angiopathy. Here we demonstrate that Abeta 1-40 and a truncated fragment, Abeta 25-35, induced death of oligodendrocytes (OLGs) in vitro in a dose-dependent manner with similar potencies. Abeta-induced OLG death was accompanied by nuclear DNA fragmentation, mitochondrial dysfunction, and cytoskeletal disintegration. Abeta activation of redox-sensitive transcription factors NF-kappaB and AP-1 and antioxidant prevention of Abeta-mediated OLG death suggest that oxidative injury contributes to Abeta cytotoxicity in OLGs. Recent demonstration of Abeta deposition and white matter abnormalities in AD implies a potential pathophysiological role for Abeta-mediated cytotoxicity of OLGs in this neurodegenerative disease.

Original languageEnglish (US)
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume21
Issue number1
StatePublished - 2001

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Amyloid beta-Peptides
Oligodendroglia
Alzheimer Disease
Neurodegenerative Diseases
Cerebral Amyloid Angiopathy
NF-kappa B
Amyloid beta-Protein Precursor
Transcription Factor AP-1
DNA Fragmentation
Oxidation-Reduction
Blood Vessels
Dementia
Transcription Factors
Antioxidants
Amino Acids
Peptides
Wounds and Injuries

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Amyloid-beta peptides are cytotoxic to oligodendrocytes. / Xu, J.; Chen, S.; Ahmed, S. H.; Chen, H.; Ku, G.; Goldberg, M. P.; Hsu, C. Y.

In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, No. 1, 2001.

Research output: Contribution to journalArticle

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