An Acetyldegron Triggers CRBN to Take Down the "Q"

Sajjan Koirala, Patrick Ryan Potts

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations. In this issue of Molecular Cell, Nguyen et al. show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.

Original languageEnglish (US)
Pages (from-to)795-796
Number of pages2
JournalMolecular Cell
Volume61
Issue number6
DOIs
StatePublished - Mar 17 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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