An Acetyldegron Triggers CRBN to Take Down the "Q"

Sajjan Koirala, Patrick Ryan Potts

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations. In this issue of Molecular Cell, Nguyen et al. show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.

Original languageEnglish (US)
Pages (from-to)795-796
Number of pages2
JournalMolecular Cell
Volume61
Issue number6
DOIs
StatePublished - Mar 17 2016

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Glutamate-Ammonia Ligase
Ubiquitin-Protein Ligases
Ubiquitination
Acetylation
Glutamine

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

An Acetyldegron Triggers CRBN to Take Down the "Q". / Koirala, Sajjan; Potts, Patrick Ryan.

In: Molecular Cell, Vol. 61, No. 6, 17.03.2016, p. 795-796.

Research output: Contribution to journalArticle

Koirala, Sajjan ; Potts, Patrick Ryan. / An Acetyldegron Triggers CRBN to Take Down the "Q". In: Molecular Cell. 2016 ; Vol. 61, No. 6. pp. 795-796.
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