An Acetyldegron Triggers CRBN to Take Down the "Q"

Sajjan Koirala; Patrick Ryan Potts

doi:10.1016/j.molcel.2016.03.003

An Acetyldegron Triggers CRBN to Take Down the "Q"

Sajjan Koirala, Patrick Ryan Potts

Physiology

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4^CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations. In this issue of Molecular Cell, Nguyen et al. show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4^CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.

Original language	English (US)
Pages (from-to)	795-796
Number of pages	2
Journal	Molecular cell
Volume	61
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2016.03.003
State	Published - Mar 17 2016

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2016.03.003

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title = "An Acetyldegron Triggers CRBN to Take Down the {"}Q{"}",

abstract = "In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations. In this issue of Molecular Cell, Nguyen et al. show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.",

author = "Sajjan Koirala and Potts, {Patrick Ryan}",

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year = "2016",

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AU - Potts, Patrick Ryan

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N2 - In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations. In this issue of Molecular Cell, Nguyen et al. show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.

AB - In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations. In this issue of Molecular Cell, Nguyen et al. show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4CRBN E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.

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ER -

An Acetyldegron Triggers CRBN to Take Down the "Q"

Abstract

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