TY - JOUR
T1 - An Activity-Mediated Transition in Transcription in Early Postnatal Neurons
AU - Stroud, Hume
AU - Yang, Marty G.
AU - Tsitohay, Yael N.
AU - Davis, Christopher P.
AU - Sherman, Maxwell A.
AU - Hrvatin, Sinisa
AU - Ling, Emi
AU - Greenberg, Michael E.
N1 - Funding Information:
We thank the members of the Greenberg laboratory for helpful discussions; P. Zhang for assistance in maintenance of the mouse colony; K. Mei and G. Boulting for advice on CGE dissections and luciferase experiments; and G. Fishell, C. Harwell, E. Griffith, S. Ashrafi, and E. Pollina for editorial assistance. This work was supported by grants from the Rett Syndrome Research Trust and the NIH ( 1RO1NS048276 ) to M.E.G. C.P.D. was supported by NIH grants T32-NS007473 and F32-NS112455 . M.G.Y. was supported by NIH grant T32EY007110 . M.A.S. was supported by NIH grant U01MH106883 and the MIT Jarve Seed Fund for Science Innovation. H.S. was supported by NARSAD and Damon Runyon and Charles A. King Trust fellowships.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020
Y1 - 2020
N2 - The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is frequently impaired in neurological disorders, such as autism and schizophrenia. However, the mechanisms that regulate postnatal brain maturation are poorly defined. By purifying neuronal subpopulations across brain development in mice, we identify a postnatal switch in the transcriptional regulatory circuits that operates in the maturing mammalian brain. We show that this developmental transition includes the formation of hundreds of cell-type-specific neuronal enhancers that appear to be modulated by neuronal activity. Once selected, these enhancers are active throughout adulthood, suggesting that their formation in early life shapes neuronal identity and regulates mature brain function.
AB - The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is frequently impaired in neurological disorders, such as autism and schizophrenia. However, the mechanisms that regulate postnatal brain maturation are poorly defined. By purifying neuronal subpopulations across brain development in mice, we identify a postnatal switch in the transcriptional regulatory circuits that operates in the maturing mammalian brain. We show that this developmental transition includes the formation of hundreds of cell-type-specific neuronal enhancers that appear to be modulated by neuronal activity. Once selected, these enhancers are active throughout adulthood, suggesting that their formation in early life shapes neuronal identity and regulates mature brain function.
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U2 - 10.1016/j.neuron.2020.06.008
DO - 10.1016/j.neuron.2020.06.008
M3 - Article
C2 - 32589877
AN - SCOPUS:85087721510
JO - Journal of Cleaner Production
JF - Journal of Cleaner Production
SN - 0959-6526
ER -