TY - JOUR
T1 - An Activity-Mediated Transition in Transcription in Early Postnatal Neurons
AU - Stroud, Hume
AU - Yang, Marty G.
AU - Tsitohay, Yael N.
AU - Davis, Christopher P.
AU - Sherman, Maxwell A.
AU - Hrvatin, Sinisa
AU - Ling, Emi
AU - Greenberg, Michael E.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/9/9
Y1 - 2020/9/9
N2 - The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is frequently impaired in neurological disorders, such as autism and schizophrenia. However, the mechanisms that regulate postnatal brain maturation are poorly defined. By purifying neuronal subpopulations across brain development in mice, we identify a postnatal switch in the transcriptional regulatory circuits that operates in the maturing mammalian brain. We show that this developmental transition includes the formation of hundreds of cell-type-specific neuronal enhancers that appear to be modulated by neuronal activity. Once selected, these enhancers are active throughout adulthood, suggesting that their formation in early life shapes neuronal identity and regulates mature brain function.
AB - The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is frequently impaired in neurological disorders, such as autism and schizophrenia. However, the mechanisms that regulate postnatal brain maturation are poorly defined. By purifying neuronal subpopulations across brain development in mice, we identify a postnatal switch in the transcriptional regulatory circuits that operates in the maturing mammalian brain. We show that this developmental transition includes the formation of hundreds of cell-type-specific neuronal enhancers that appear to be modulated by neuronal activity. Once selected, these enhancers are active throughout adulthood, suggesting that their formation in early life shapes neuronal identity and regulates mature brain function.
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U2 - 10.1016/j.neuron.2020.06.008
DO - 10.1016/j.neuron.2020.06.008
M3 - Article
C2 - 32589877
AN - SCOPUS:85087721510
SN - 0896-6273
VL - 107
SP - 874-890.e8
JO - Neuron
JF - Neuron
IS - 5
ER -