An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents

Fang Zhang, Guiyang Hao, Mengle Shao, Kien Nham, Yu An, Qiong Wang, Yi Zhu, Christine Kusminski, Gedaa Hassan, Rana K Gupta, Qiwei Zhai, Xiankai Sun, Philipp E Scherer, Orhan K Oz

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

[18F]Fluorodeoxyglucose-PET/CT (18F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as 18F-FDG through PET/CT or [123/125I]-β-methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads. Histological and gene expression analyses validate these regions as bona fide fat pads. Our findings indicate that fat depots of rodents show a high degree of topological similarity to those of humans. Studies involving both glucose and lipid tracers indicate differential preferences for these substrates in different depots and also suggest that fatty acid-based visualized approaches may reveal additional brown adipose tissue and beige depots in humans. 18F-FDG-PET/CT imaging in humans has been invaluable for visualizing metabolically active adipose tissues. Using PET/CT and SPECT/CT for imaging glucose and lipid metabolism, respectively, in mice, Zhang et al. define an atlas of fat depots, topologically analogous to those observed in humans.

Original languageEnglish (US)
Pages (from-to)252-262.e3
JournalCell Metabolism
Volume27
Issue number1
DOIs
StatePublished - Jan 9 2018

Fingerprint

Forensic Anthropology
Atlases
Adipose Tissue
Rodentia
Fluorodeoxyglucose F18
Fats
Glucose
Fatty Acids
Brown Adipose Tissue
Lipid Metabolism
Obesity
Lipids
Gene Expression
Single Photon Emission Computed Tomography Computed Tomography

Keywords

  • BAT
  • beige
  • bona fide thermogenic fat tissues
  • glucose or fatty acid imaging tracers
  • human-like
  • imaging
  • marker genes
  • morphology
  • PET/CT
  • SPECT/CT

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

An Adipose Tissue Atlas : An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents. / Zhang, Fang; Hao, Guiyang; Shao, Mengle; Nham, Kien; An, Yu; Wang, Qiong; Zhu, Yi; Kusminski, Christine; Hassan, Gedaa; Gupta, Rana K; Zhai, Qiwei; Sun, Xiankai; Scherer, Philipp E; Oz, Orhan K.

In: Cell Metabolism, Vol. 27, No. 1, 09.01.2018, p. 252-262.e3.

Research output: Contribution to journalArticle

Zhang, Fang ; Hao, Guiyang ; Shao, Mengle ; Nham, Kien ; An, Yu ; Wang, Qiong ; Zhu, Yi ; Kusminski, Christine ; Hassan, Gedaa ; Gupta, Rana K ; Zhai, Qiwei ; Sun, Xiankai ; Scherer, Philipp E ; Oz, Orhan K. / An Adipose Tissue Atlas : An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents. In: Cell Metabolism. 2018 ; Vol. 27, No. 1. pp. 252-262.e3.
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