An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius

Hye Hyun Yoo, Jeong Hill Park, Sung Won Kwon

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC50 value of 0.31 μg/ml, a level of inhibition comparable to that of tamoxifen (IC50 = 0.43 μg/ml).

Original languageEnglish (US)
Pages (from-to)2783-2785
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume70
Issue number11
DOIs
StatePublished - 2006

Keywords

  • Anti-estrogenic activity
  • Bioassay-linked HPLC-ELSD
  • Carthamus tinctorius
  • Ishikawa cell
  • Tracheloside

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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