Abstract
The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC50 value of 0.31 μg/ml, a level of inhibition comparable to that of tamoxifen (IC50 = 0.43 μg/ml).
Original language | English (US) |
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Pages (from-to) | 2783-2785 |
Number of pages | 3 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 70 |
Issue number | 11 |
DOIs | |
State | Published - 2006 |
Keywords
- Anti-estrogenic activity
- Bioassay-linked HPLC-ELSD
- Carthamus tinctorius
- Ishikawa cell
- Tracheloside
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry