An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

L. A. Pennacchio; M. Olivier; J. A. Hubacek; J. C. Cohen; D. R. Cox; J. C. Fruchart; R. M. Krauss; E. M. Rubin

doi:10.1126/science.1064852

An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

L. A. Pennacchio, M. Olivier, J. A. Hubacek, J. C. Cohen, D. R. Cox, J. C. Fruchart, R. M. Krauss, E. M. Rubin

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Abstract

Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.

Original language	English (US)
Pages (from-to)	169-173
Number of pages	5
Journal	Science
Volume	294
Issue number	5540
DOIs	https://doi.org/10.1126/science.1064852
State	Published - Oct 5 2001

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title = "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing",

abstract = "Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.",

author = "Pennacchio, {L. A.} and M. Olivier and Hubacek, {J. A.} and Cohen, {J. C.} and Cox, {D. R.} and Fruchart, {J. C.} and Krauss, {R. M.} and Rubin, {E. M.}",

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T1 - An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

AU - Pennacchio, L. A.

AU - Olivier, M.

AU - Hubacek, J. A.

AU - Cohen, J. C.

AU - Cox, D. R.

AU - Fruchart, J. C.

AU - Krauss, R. M.

AU - Rubin, E. M.

PY - 2001/10/5

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N2 - Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.

AB - Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.

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An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

Abstract

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