@article{d1ec059cb0954058bf42cfe33cef344b,
title = "An apparent 1,25-dihydroxyvitamin D-independent stimulation of intestinal calcium absorption in patients with paget disease of bone during a short-term diphosphonate therapy",
abstract = "Six patients with Paget disease of bone were treated with a 6-mo course of disodium-ethane-1-hydroxy-1, 1-diphosphate (EHDP) at a dosage of 5 mg/kg/day (one patient) or 20 mg/kg/day (five patients). In addition to symptomatic and biochemical improvement which persisted 3 mo after discontinuance of therapy, EHDP resulted in a significant increase in intestinal calcium absorption that was not correlated with a change in serum 1α,25-(OH)2-vitamin D concentration. EHDP appears to stimulate intestinal calcium transport by either a vitamin D independent process or by an increased intestinal mucosal cell sensitivity to vitamin D.",
author = "Norman, {Daniel A.} and Zerwekh, {Joseph E.} and Pak, {Charles Y C}",
note = "Funding Information: From the Sections of Gastroenterology and Mineral Metabolism, the Department of lniernal Medicine, the University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas. Tex. Supported by USPHS Grants ROI-AM16061 and MOI-RR00633, and by a grant from Proctor and Gamble Co. Received for publication August 27, 1980. Address reprint requests to: Dr. Charles Pak, Department of Internal Medicine, the University of Texas Health Science Center at Dallas. Southwestern Medical School, 5323 Harry Hines Blvd.. Dallas, TX 75235. 1~ 1981 by Grune & Stratton, Inc. 0026-0495/81/3003-0012$01.00/0",
year = "1981",
month = mar,
doi = "10.1016/0026-0495(81)90154-2",
language = "English (US)",
volume = "30",
pages = "290--292",
journal = "Metabolism",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "3",
}