An economic evaluation of two ototopical treatments for acute otitis media in tympanostomy tube patients

Peter S. Roland, Curtis R. Waycaster, G. Michael Wall, Jeffrey D. Glass

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective: The goal of this research was to determine the cost-effectiveness of ciprofloxacin 0.3%/dexamethasone 0.1% (CD) otic suspension versus ofloxacin 0.3% otic solution (OFX) for treatment of acute otitis media in tympanostomy tube patients. Methods: A decision-analytic model was used to emulate the ototopical treatment of acute otitis media in patients with tympanostomy tubes. The economic outcome was the cost per otorrhea-free day (OFD) achieved per episode of care. Three tiers of antimicrobial therapy were modeled, with each successive tier representing the retreatment of clinical failures from the preceding tier. First-tier therapy compared CD and OFX using outcome measures obtained from a randomized clinical trial (n = 599). Second-tier therapy modeled the use of amoxicillin/clavulanate (ACA) using outcome measures obtained from a physician survey and medical literature. Third-tier therapy was modeled as pathogen-specific and curative. It could follow one of three pathways: 1) intramuscular ceftriaxone; 2) oral fluconazole; or 3) hospitalization for intravenous antibiotics. Third-tier outcomes were based on a physician survey. Cost data were obtained from standard references and presented from a payer perspective. Results: The expected therapeutic costs were $249.40 for the CD pathway and $265.44 for the OFX pathway. The estimated number of OFDs per episode of care was 25.88 for the CD pathway and 23.86 for the OFX pathway. The cost-effectiveness ratios for CD and OFX therapies were $9.64 and $11.13 per OFD, respectively. Conclusion: CD is both more effective and less costly than OFX for the treatment of acute otitis media in patients with tympanostomy tubes.

Original languageEnglish (US)
Pages (from-to)219-226
Number of pages8
JournalValue in Health
Volume9
Issue number4
DOIs
StatePublished - Jan 1 2006

Keywords

  • Ciprofloxacin
  • Cost-effectiveness
  • Decision analysis
  • Dexamethasone
  • Ofloxacin
  • Otorrhea
  • Tympanostomy

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health

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