Abstract
An efficient and general method for the synthesis of 2, 6-disubstituted styrènes 5 via the palladiumcatalyzed [4+2] homobenzannulation of conjugated enynes 4 was developed. In all cases, the reactions proceeded in regiospecific manner, affording the disubstituted styrènes, bearing various functional groups at the 2 and 6 positions of the benzene ring, as a single reaction product in good to excellent yields. Initial attempts at cross-cycloaddition of two different enynes indicated low degrees of chemoselectivity of this process. Accordingly, the cross-dimerization products 6 in all cases were accompanied with notable amounts of the chemoisomeric homodimers 5.
Original language | English (US) |
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Pages (from-to) | 7022-7025 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 63 |
Issue number | 20 |
DOIs | |
State | Published - Oct 2 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry