An essential role in liver development for transcription factor XBP-1

Andreas M. Reimold, Amit Etkin, Isabelle Clauss, Andrew Perkins, Daniel S. Friend, John Zhang, Heidi F. Horton, Andrew Scott, Stuart H. Orkin, Michael C. Byrne, Michael J. Grusby, Laurie H. Glimcher

Research output: Contribution to journalArticle

397 Scopus citations

Abstract

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalGenes and Development
Volume14
Issue number2
StatePublished - Jan 15 2000

Keywords

  • Acute phase protein
  • Apoptosis
  • CREB/ATF family
  • Hepatocyte
  • Liver development
  • Transcription factors

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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  • Cite this

    Reimold, A. M., Etkin, A., Clauss, I., Perkins, A., Friend, D. S., Zhang, J., Horton, H. F., Scott, A., Orkin, S. H., Byrne, M. C., Grusby, M. J., & Glimcher, L. H. (2000). An essential role in liver development for transcription factor XBP-1. Genes and Development, 14(2), 152-157.