An increase in NMDA-sensitive [3H]glutamate and [3H]kainate binding in hippocampus 24 hours after PCP

Xue Min Gao, Carol A. Tamminga

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Considerable research has identified a variety of acute PCP-induced biochemical changes in brain; but, little study has been devoted to characterizing delayed PCP-induced actions. These could potentially be associated with the prolonged psychotomimetic effects of the drug in humans. Here we studied delayed PCP-induced alterations in glutamate receptor subtype binding across a range of PCP doses, based on our previous findings of delayed regional cerebral metabolism changes with PCP. We report that 24 h after a single dose, PCP increases N-methyl-d-aspartate (NMDA)-sensitive [3H]glutamate binding in hippocampus (CA1) in an apparent dose-sensitive manner; no other dose-sensitive regional changes in NMDA binding sites were apparent in a sampling of 19 brain regions. [3H]kainate binding sites were increased in CA3 and dentate gyrus, but only at the high drug dose. Moreover, PCP appeared to have a general delayed effect in upregulating NMDA receptor binding in limbic-associated brain areas at its middle dose, and in upregulating [3H]kainate binding in neocortical and limbic area at its high dose. No PCP effects were noted on AMPA receptor binding. These delayed actions of PCP may be informative about the mechanism of PCP psychosis.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalNeuroscience Letters
Volume174
Issue number2
DOIs
StatePublished - Jun 20 1994

Fingerprint

Kainic Acid
Aspartic Acid
Glutamic Acid
Hippocampus
Brain
Binding Sites
AMPA Receptors
Dentate Gyrus
Glutamate Receptors
Pharmaceutical Preparations
Psychotic Disorders
Research

Keywords

  • Autoradiography
  • Hippocampus
  • Kainate
  • N-Methyl-d-aspartate
  • Phencyclidine
  • Psychosis
  • Receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

An increase in NMDA-sensitive [3H]glutamate and [3H]kainate binding in hippocampus 24 hours after PCP. / Gao, Xue Min; Tamminga, Carol A.

In: Neuroscience Letters, Vol. 174, No. 2, 20.06.1994, p. 149-153.

Research output: Contribution to journalArticle

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