An interleukin-4-induced transcription factor: IL-4 Stat

Jinzhao Hou, Ulrike Schindler, William J. Henzel, Tze Chun Ho, Mike Brasseur, Steven L. McKnight

Research output: Contribution to journalArticle

699 Scopus citations

Abstract

Interleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1. Imbalance of these T lymphocyte subsets has been implicated in immunological diseases including allergy, inflammation, and autoimmune disease. IL-4 may mediate its biological effects, at least in part, by activating a tyrosine-phosphorylated DNA binding protein. This protein has now been purified and its encoding gene cloned. Examination of the primary amino acid sequence of this protein indicates that it is a member of the signal transducers and activators of transcription (Stat) family of DNA binding proteins, hereby designated IL-4 Stat. Study of the inhibitory activities of phosphotyrosine-containing peptides derived from the intracellular domain of the IL-4 receptor provided evidence for direct coupling of receptor and transcription factor during the IL-4 Stat activation cycle. Such observations indicate that IL-4 Stat has the same functional domain for both receptor coupling and dimerization.

Original languageEnglish (US)
Pages (from-to)1701-1706
Number of pages6
JournalScience
Volume265
Issue number5179
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

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    Hou, J., Schindler, U., Henzel, W. J., Ho, T. C., Brasseur, M., & McKnight, S. L. (1994). An interleukin-4-induced transcription factor: IL-4 Stat. Science, 265(5179), 1701-1706. https://doi.org/10.1126/science.8085155