An investigation of possible effects of high-frequency ultrasound on cellular integrity of cultured fibroblasts

P. Anthony N Chandraratna, Jacqueline Gallet, Joie P. Jones, Yung Do, Rajah Gunawardana, Yadi Narang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Several investigators have demonstrated the feasibility of imaging at the cellular level using acoustical microscopy. It has also been proposed that acoustical microscopy technology might be adopted for in vivo applications. Before such applications are implemented, it is important to demonstrate that any major deleterious effects are highly unlikely. To this end, we have repeatedly scanned NIH/3T3 mouse fibroblasts in culture using an Olympus UH3 acoustical microscope operating at 600 MHz. No adverse effects were observed even after exposures for 1 h. Spatial peak temporal averaged intensities were estimated to be below 300 mW/cm2.

Original languageEnglish (US)
Pages (from-to)911-914
Number of pages4
JournalUltrasound in Medicine and Biology
Volume24
Issue number6
DOIs
StatePublished - Jul 1 1998

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Keywords

  • Acoustical microscopy
  • Bioeffects
  • Mouse fibroblasts

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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