An investigation of the effect of radioactive labeling of DNA on excision repair in UV-irradiated human fibroblasts

E. K. Ehmann, E. C. Friedberg

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Previous studies on the kinetics of thymine dimer excision and unscheduled DNA synthesis in UV-irradiated human fibroblasts showed a significant discrepancy in these two parameters (Ehmann et al., 1978. Biophys. J. 22: 249). In the present study we have investigated the effect of the level of the radioactive isotope used for labeling cells on the kinetics of a parameter that directly measures thymine dimer excision. We find no significant differences in the kinetics of this parameter in cells lightly or heavily labeled with radioactive thymidine.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalBiophysical journal
Volume31
Issue number2
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biophysics

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