An MRI-based attenuation correction method for combined PET/MRI applications

Baowei Fei, Xiaofeng Yang, Hesheng Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

We are developing MRI-based attenuation correction methods for PET images. PET has high sensitivity but relatively low resolution and little anatomic details. MRI can provide excellent anatomical structures with high resolution and high soft tissue contrast. MRI can be used to delineate tumor boundaries and to provide an anatomic reference for PET, thereby improving quantitation of PET data. Combined PET/MRI can offer metabolic, functional and anatomic information and thus can provide a powerful tool to study the mechanism of a variety of diseases. Accurate attenuation correction represents an essential component for the reconstruction of artifact-free, quantitative PET images. Unfortunately, the present design of hybrid PET/MRI does not offer measured attenuation correction using a transmission scan. This problem may be solved by deriving attenuation maps from corresponding anatomic MR images. Our approach combines image registration, classification, and attenuation correction in a single scheme. MR images and the preliminary reconstruction of PET data are first registered using our automatic registration method. MRI images are then classified into different tissue types using our multiscale fuzzy C-mean classification method. The voxels of classified tissue types are assigned theoretical tissue-dependent attenuation coefficients to generate attenuation correction factors. Corrected PET emission data are then reconstructed using a threedimensional filtered back projection method and an order subset expectation maximization method. Results from simulated images and phantom data demonstrated that our attenuation correction method can improve PET data quantitation and it can be particularly useful for combined PET/MRI applications.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - Jun 22 2009
Externally publishedYes
EventMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 10 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7262
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/8/092/10/09

Fingerprint

Magnetic resonance imaging
attenuation
Tissue
Computer-Assisted Image Processing
Image registration
Artifacts
attenuation coefficients
Set theory
set theory
artifacts
Tumors
tumors
projection
sensitivity
high resolution
Neoplasms

Keywords

  • Attenuation correction
  • Brain imaging
  • Classification
  • MRI
  • PET
  • Registration
  • Segmentation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Fei, B., Yang, X., & Wang, H. (2009). An MRI-based attenuation correction method for combined PET/MRI applications. In Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging [726208] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7262). https://doi.org/10.1117/12.813755

An MRI-based attenuation correction method for combined PET/MRI applications. / Fei, Baowei; Yang, Xiaofeng; Wang, Hesheng.

Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2009. 726208 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7262).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fei, B, Yang, X & Wang, H 2009, An MRI-based attenuation correction method for combined PET/MRI applications. in Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging., 726208, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, United States, 2/8/09. https://doi.org/10.1117/12.813755
Fei B, Yang X, Wang H. An MRI-based attenuation correction method for combined PET/MRI applications. In Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2009. 726208. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.813755
Fei, Baowei ; Yang, Xiaofeng ; Wang, Hesheng. / An MRI-based attenuation correction method for combined PET/MRI applications. Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2009. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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