An MRI-compatible system for focused ultrasound experiments in small animal models

Rajiv Chopra, Laura Curiel, Robert Staruch, Laetitia Morrison, Kullervo Hynynen

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The development of novel MRI-guided therapeutic ultrasound methods including potentiated drug delivery and targeted thermal ablation requires extensive testing in small animals such as rats and mice due to the widespread use of these species as models of disease. An MRI-compatible, computer-controlled three-axis positioning system was constructed to deliver focused ultrasound exposures precisely to a target anatomy in small animals for high-throughput preclinical drug delivery studies. Each axis was constructed from custom-made nonmagnetic linear ball stages driven by piezoelectric actuators and optical encoders. A range of motion of 5×5×2.5 cm3 was achieved, and initial bench top characterization demonstrated the ability to deliver ultrasound to the brain with a spatial accuracy of 0.3 mm. Operation of the positioning system within the bore of a clinical 3 T MR imager was feasible, and simultaneous motion and MR imaging did not result in any mutual interference. The system was evaluated in its ability to deliver precise sonications within the mouse brain, linear scanned exposures in a rat brain for blood barrier disruption, and circular scans for controlled heating under MR temperature feedback. Initial results suggest that this is a robust and precise apparatus for use in the investigation of novel ultrasound-based therapeutic strategies in small animal preclinical models.

Original languageEnglish (US)
Pages (from-to)1867-1874
Number of pages8
JournalMedical Physics
Volume36
Issue number5
DOIs
StatePublished - 2009

Fingerprint

Animal Models
Sonication
Brain
Articular Range of Motion
Blood-Brain Barrier
Pharmaceutical Preparations
Heating
Anatomy
Hot Temperature
Temperature
Therapeutics

Keywords

  • MRI compatible
  • MRI-guided focused ultrasound
  • Positioning
  • Preclinical

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

An MRI-compatible system for focused ultrasound experiments in small animal models. / Chopra, Rajiv; Curiel, Laura; Staruch, Robert; Morrison, Laetitia; Hynynen, Kullervo.

In: Medical Physics, Vol. 36, No. 5, 2009, p. 1867-1874.

Research output: Contribution to journalArticle

Chopra, R, Curiel, L, Staruch, R, Morrison, L & Hynynen, K 2009, 'An MRI-compatible system for focused ultrasound experiments in small animal models', Medical Physics, vol. 36, no. 5, pp. 1867-1874. https://doi.org/10.1118/1.3115680
Chopra, Rajiv ; Curiel, Laura ; Staruch, Robert ; Morrison, Laetitia ; Hynynen, Kullervo. / An MRI-compatible system for focused ultrasound experiments in small animal models. In: Medical Physics. 2009 ; Vol. 36, No. 5. pp. 1867-1874.
@article{1681995f0aea4a89a68952de6930717e,
title = "An MRI-compatible system for focused ultrasound experiments in small animal models",
abstract = "The development of novel MRI-guided therapeutic ultrasound methods including potentiated drug delivery and targeted thermal ablation requires extensive testing in small animals such as rats and mice due to the widespread use of these species as models of disease. An MRI-compatible, computer-controlled three-axis positioning system was constructed to deliver focused ultrasound exposures precisely to a target anatomy in small animals for high-throughput preclinical drug delivery studies. Each axis was constructed from custom-made nonmagnetic linear ball stages driven by piezoelectric actuators and optical encoders. A range of motion of 5×5×2.5 cm3 was achieved, and initial bench top characterization demonstrated the ability to deliver ultrasound to the brain with a spatial accuracy of 0.3 mm. Operation of the positioning system within the bore of a clinical 3 T MR imager was feasible, and simultaneous motion and MR imaging did not result in any mutual interference. The system was evaluated in its ability to deliver precise sonications within the mouse brain, linear scanned exposures in a rat brain for blood barrier disruption, and circular scans for controlled heating under MR temperature feedback. Initial results suggest that this is a robust and precise apparatus for use in the investigation of novel ultrasound-based therapeutic strategies in small animal preclinical models.",
keywords = "MRI compatible, MRI-guided focused ultrasound, Positioning, Preclinical",
author = "Rajiv Chopra and Laura Curiel and Robert Staruch and Laetitia Morrison and Kullervo Hynynen",
year = "2009",
doi = "10.1118/1.3115680",
language = "English (US)",
volume = "36",
pages = "1867--1874",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "5",

}

TY - JOUR

T1 - An MRI-compatible system for focused ultrasound experiments in small animal models

AU - Chopra, Rajiv

AU - Curiel, Laura

AU - Staruch, Robert

AU - Morrison, Laetitia

AU - Hynynen, Kullervo

PY - 2009

Y1 - 2009

N2 - The development of novel MRI-guided therapeutic ultrasound methods including potentiated drug delivery and targeted thermal ablation requires extensive testing in small animals such as rats and mice due to the widespread use of these species as models of disease. An MRI-compatible, computer-controlled three-axis positioning system was constructed to deliver focused ultrasound exposures precisely to a target anatomy in small animals for high-throughput preclinical drug delivery studies. Each axis was constructed from custom-made nonmagnetic linear ball stages driven by piezoelectric actuators and optical encoders. A range of motion of 5×5×2.5 cm3 was achieved, and initial bench top characterization demonstrated the ability to deliver ultrasound to the brain with a spatial accuracy of 0.3 mm. Operation of the positioning system within the bore of a clinical 3 T MR imager was feasible, and simultaneous motion and MR imaging did not result in any mutual interference. The system was evaluated in its ability to deliver precise sonications within the mouse brain, linear scanned exposures in a rat brain for blood barrier disruption, and circular scans for controlled heating under MR temperature feedback. Initial results suggest that this is a robust and precise apparatus for use in the investigation of novel ultrasound-based therapeutic strategies in small animal preclinical models.

AB - The development of novel MRI-guided therapeutic ultrasound methods including potentiated drug delivery and targeted thermal ablation requires extensive testing in small animals such as rats and mice due to the widespread use of these species as models of disease. An MRI-compatible, computer-controlled three-axis positioning system was constructed to deliver focused ultrasound exposures precisely to a target anatomy in small animals for high-throughput preclinical drug delivery studies. Each axis was constructed from custom-made nonmagnetic linear ball stages driven by piezoelectric actuators and optical encoders. A range of motion of 5×5×2.5 cm3 was achieved, and initial bench top characterization demonstrated the ability to deliver ultrasound to the brain with a spatial accuracy of 0.3 mm. Operation of the positioning system within the bore of a clinical 3 T MR imager was feasible, and simultaneous motion and MR imaging did not result in any mutual interference. The system was evaluated in its ability to deliver precise sonications within the mouse brain, linear scanned exposures in a rat brain for blood barrier disruption, and circular scans for controlled heating under MR temperature feedback. Initial results suggest that this is a robust and precise apparatus for use in the investigation of novel ultrasound-based therapeutic strategies in small animal preclinical models.

KW - MRI compatible

KW - MRI-guided focused ultrasound

KW - Positioning

KW - Preclinical

UR - http://www.scopus.com/inward/record.url?scp=65449147886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65449147886&partnerID=8YFLogxK

U2 - 10.1118/1.3115680

DO - 10.1118/1.3115680

M3 - Article

VL - 36

SP - 1867

EP - 1874

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 5

ER -