An MRI-compatible three-axis focused ultrasound system for performing drug delivery studies in small animal models

Adam C. Waspe, Anthony Chau, Aleksandra Kukic, Rajiv Chopra, Kullervo Hynynen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MRI-guided focused-ultrasound is a non-invasive technique that can enhance the delivery of therapeutic agents. The objective of this work was to develop a focused-ultrasound system for preclinical research in small animals that is capable of sonicating with high spatial precision within a closed-bore MRI. The system features a computer-controlled, non-magnetic, three-axis positioning system that uses piezoelectric actuators and linear optical encoders to position a focused-ultrasound transducer to targeted tissues under MRI guidance. The actuator and encoder signals are transmitted through low-pass-filtered connectors on a grounded RF-penetration panel to prevent artifacts during image acquisition. The transducer is attached to the positioning system by a rigid arm and is submerged within a closed water tank. The arm passes into the tank through flexible bellows to ensure that the system remains sealed. An RF coil acquires high-resolution images in the vicinity of the target tissue. An aperture on the water tank, centered about the RF coil, provides an access point for target sonication. Registration between ultrasound and MRI coordinates involves sonicating a temperature-sensitive phantom and measuring the centroid of the thermal focal zone in 3D with MR thermometry. Linear distances of 5 cm with a positioning resolution of 0.05 mm can be achieved for each axis. The system was operated successfully on MRI scanners from different vendors at both 1.5 and 3.0 T, and simultaneous motion and imaging was possible without any mutual interference or imaging artifacts. This system is used for high-throughput small-animal experiments to study the efficacy of ultrasound-enhanced drug delivery.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2010 - Ultrasonic Imaging, Tomography, and Therapy
DOIs
StatePublished - Sep 24 2010
EventMedical Imaging 2010 - Ultrasonic Imaging, Tomography, and Therapy - San Diego, CA, United States
Duration: Feb 14 2010Feb 15 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7629
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2010 - Ultrasonic Imaging, Tomography, and Therapy
CountryUnited States
CitySan Diego, CA
Period2/14/102/15/10

Keywords

  • MR thermometry
  • MRI-compatible positioning system
  • MRI-guided focused ultrasound
  • focused-ultrasound-enhanced drug delivery
  • high-intensity focused ultrasound
  • small animal imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Waspe, A. C., Chau, A., Kukic, A., Chopra, R., & Hynynen, K. (2010). An MRI-compatible three-axis focused ultrasound system for performing drug delivery studies in small animal models. In Medical Imaging 2010 - Ultrasonic Imaging, Tomography, and Therapy [76290U] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7629). https://doi.org/10.1117/12.844253