An overview of MYC and its interactome.

Maralice Conacci-Sorrell, Lisa McFerrin, Robert N. Eisenman

Research output: Contribution to journalReview article

Abstract

This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in medicine
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Gene Regulatory Networks
Animals
Sensors
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

An overview of MYC and its interactome. / Conacci-Sorrell, Maralice; McFerrin, Lisa; Eisenman, Robert N.

In: Cold Spring Harbor perspectives in medicine, Vol. 4, No. 1, 01.01.2014.

Research output: Contribution to journalReview article

@article{d5275d23690f48309faa9e631844a0d0,
title = "An overview of MYC and its interactome.",
abstract = "This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.",
author = "Maralice Conacci-Sorrell and Lisa McFerrin and Eisenman, {Robert N.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1101/cshperspect.a014357",
language = "English (US)",
volume = "4",
journal = "Cold Spring Harbor perspectives in medicine",
issn = "2157-1422",
publisher = "Cold Spring Harbor Laboratory Press",
number = "1",

}

TY - JOUR

T1 - An overview of MYC and its interactome.

AU - Conacci-Sorrell, Maralice

AU - McFerrin, Lisa

AU - Eisenman, Robert N.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.

AB - This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.

UR - http://www.scopus.com/inward/record.url?scp=84906538888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906538888&partnerID=8YFLogxK

U2 - 10.1101/cshperspect.a014357

DO - 10.1101/cshperspect.a014357

M3 - Review article

VL - 4

JO - Cold Spring Harbor perspectives in medicine

JF - Cold Spring Harbor perspectives in medicine

SN - 2157-1422

IS - 1

ER -