An ultramicroscopic study on the distribution of Müller cell processes in the outer retinal layers of the zebrafish

Eunju Lee, Byung Soo Chang, Ga Hee Mun, Yoon Hee Chung, Jaehyup Kim, Dong Hoon Shin

Research output: Contribution to journalArticle

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Abstract

The zebrafish, Brachydanio rerio, is a good model for studying the development of various organs. We have assayed the distribution pattern of Müller cell processes in zebrafish retinas by electron microscopy. In the outer nuclear (ON) layer, multiple layers of Müller cell processes were present along both sides of the large pyramidal endings of the synaptic terminals. We found that the inner segments (ISs) of the zebrafish photoreceptors (PRs), including the cones, double cones and rods, were arranged in different planes, and that the Müller cell processes formed multilayered sheaths around virtually all PR compartments except their outer segments. Thus, Müller cell processes beyond the outer limiting membrane (OLM) are more easily observed in zebrafish retina than in the retinas of other species. To our knowledge, this is the first study to show the exact ultrastructural distribution of Müller cell processes around the OLM and the PR layer in zebrafish retina.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalAnnals of Anatomy
Volume187
Issue number1
DOIs
StatePublished - Mar 2005

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Keywords

  • Electron microscope
  • Müller cell
  • Photoreceptor
  • Retina
  • Zebrafish

ASJC Scopus subject areas

  • Anatomy
  • Developmental Biology

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