An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection: A case report and review of the literature

R. A. Glover, D. J. Piaquadio, S. Kern, C. J. Cockerell

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background. - Syphilis has been reported to assume unusual clinical appearances and to exhibit unusual courses in patients infected with the human immunodeficiency virus (HIV) type 1. We recently observed a distinct manifestation of syphilis in an HIV-infected patient with features not previously described. Observations. - A 38-year-old HIV-seropositive homosexual man presented with fever, chills, malaise, and a cutaneous eruption consisting of indurated, shiny, erythematous plaques that were confluent on the face and scalp leading to alopecia and extreme tautness of the skin. Initial clinical diagnoses included lymphoreticular malignancy and infection. Although cultures yielded Staphylococcus aureus, a skin biopsy specimen was diagnostic of syphilis. Conclusions. - This case demonstrates an unusual clinical manifestation of syphilis in a patient with HIV infection and emphasizes the importance of considering cutaneous secondary syphilis in the differential diagnosis of virtually any inflammatory cutaneous disorder in HIV-seropositive individuals.

Original languageEnglish (US)
Pages (from-to)530-534
Number of pages5
JournalArchives of Dermatology
Volume128
Issue number4
DOIs
StatePublished - 1992

Fingerprint

Virus Diseases
Syphilis
HIV
Skin
cutaneous Syphilis
Chills
Alopecia
Scalp
Staphylococcus aureus
HIV-1
Differential Diagnosis
Fever
Biopsy
Secondary syphilis
Infection
Neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection : A case report and review of the literature. / Glover, R. A.; Piaquadio, D. J.; Kern, S.; Cockerell, C. J.

In: Archives of Dermatology, Vol. 128, No. 4, 1992, p. 530-534.

Research output: Contribution to journalArticle

@article{de127bc7d62f406bb4fa851b4189371e,
title = "An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection: A case report and review of the literature",
abstract = "Background. - Syphilis has been reported to assume unusual clinical appearances and to exhibit unusual courses in patients infected with the human immunodeficiency virus (HIV) type 1. We recently observed a distinct manifestation of syphilis in an HIV-infected patient with features not previously described. Observations. - A 38-year-old HIV-seropositive homosexual man presented with fever, chills, malaise, and a cutaneous eruption consisting of indurated, shiny, erythematous plaques that were confluent on the face and scalp leading to alopecia and extreme tautness of the skin. Initial clinical diagnoses included lymphoreticular malignancy and infection. Although cultures yielded Staphylococcus aureus, a skin biopsy specimen was diagnostic of syphilis. Conclusions. - This case demonstrates an unusual clinical manifestation of syphilis in a patient with HIV infection and emphasizes the importance of considering cutaneous secondary syphilis in the differential diagnosis of virtually any inflammatory cutaneous disorder in HIV-seropositive individuals.",
author = "Glover, {R. A.} and Piaquadio, {D. J.} and S. Kern and Cockerell, {C. J.}",
year = "1992",
doi = "10.1001/archderm.128.4.530",
language = "English (US)",
volume = "128",
pages = "530--534",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection

T2 - A case report and review of the literature

AU - Glover, R. A.

AU - Piaquadio, D. J.

AU - Kern, S.

AU - Cockerell, C. J.

PY - 1992

Y1 - 1992

N2 - Background. - Syphilis has been reported to assume unusual clinical appearances and to exhibit unusual courses in patients infected with the human immunodeficiency virus (HIV) type 1. We recently observed a distinct manifestation of syphilis in an HIV-infected patient with features not previously described. Observations. - A 38-year-old HIV-seropositive homosexual man presented with fever, chills, malaise, and a cutaneous eruption consisting of indurated, shiny, erythematous plaques that were confluent on the face and scalp leading to alopecia and extreme tautness of the skin. Initial clinical diagnoses included lymphoreticular malignancy and infection. Although cultures yielded Staphylococcus aureus, a skin biopsy specimen was diagnostic of syphilis. Conclusions. - This case demonstrates an unusual clinical manifestation of syphilis in a patient with HIV infection and emphasizes the importance of considering cutaneous secondary syphilis in the differential diagnosis of virtually any inflammatory cutaneous disorder in HIV-seropositive individuals.

AB - Background. - Syphilis has been reported to assume unusual clinical appearances and to exhibit unusual courses in patients infected with the human immunodeficiency virus (HIV) type 1. We recently observed a distinct manifestation of syphilis in an HIV-infected patient with features not previously described. Observations. - A 38-year-old HIV-seropositive homosexual man presented with fever, chills, malaise, and a cutaneous eruption consisting of indurated, shiny, erythematous plaques that were confluent on the face and scalp leading to alopecia and extreme tautness of the skin. Initial clinical diagnoses included lymphoreticular malignancy and infection. Although cultures yielded Staphylococcus aureus, a skin biopsy specimen was diagnostic of syphilis. Conclusions. - This case demonstrates an unusual clinical manifestation of syphilis in a patient with HIV infection and emphasizes the importance of considering cutaneous secondary syphilis in the differential diagnosis of virtually any inflammatory cutaneous disorder in HIV-seropositive individuals.

UR - http://www.scopus.com/inward/record.url?scp=0026589582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026589582&partnerID=8YFLogxK

U2 - 10.1001/archderm.128.4.530

DO - 10.1001/archderm.128.4.530

M3 - Article

C2 - 1580662

AN - SCOPUS:0026589582

VL - 128

SP - 530

EP - 534

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 4

ER -