An unusually “complex” glomerulonephritis

Gabriela Martinez-Zayas; Daniel Savino; Sumit Kumar; Kathryn H. Dao

doi:10.1080/08998280.2022.2073106

An unusually “complex” glomerulonephritis

Gabriela Martinez-Zayas, Daniel Savino, Sumit Kumar, Kathryn H. Dao

Research output: Contribution to journal › Article › peer-review

Abstract

A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. This case report explores the possible relationship between COVID-19 vaccines and the immune response in the setting of chronic HIV.

Original language	English (US)
Pages (from-to)	531-533
Number of pages	3
Journal	Baylor University Medical Center Proceedings
Volume	35
Issue number	4
DOIs	https://doi.org/10.1080/08998280.2022.2073106
State	Published - 2022

Keywords

COVID vaccine
glomerulonephritis
granulomatosis with polyangiitis
human immunodeficiency virus
immune complexes
type III hypersensitivity

ASJC Scopus subject areas

General Medicine

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10.1080/08998280.2022.2073106

Cite this

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title = "An unusually “complex” glomerulonephritis",

abstract = "A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. This case report explores the possible relationship between COVID-19 vaccines and the immune response in the setting of chronic HIV.",

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author = "Gabriela Martinez-Zayas and Daniel Savino and Sumit Kumar and Dao, {Kathryn H.}",

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AU - Kumar, Sumit

AU - Dao, Kathryn H.

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AB - A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. This case report explores the possible relationship between COVID-19 vaccines and the immune response in the setting of chronic HIV.

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KW - glomerulonephritis

KW - granulomatosis with polyangiitis

KW - human immunodeficiency virus

KW - immune complexes

KW - type III hypersensitivity

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An unusually “complex” glomerulonephritis

Abstract

Keywords

ASJC Scopus subject areas

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