Abstract
Thirty-two evaluable patients with squamous cell cancer of the cervix were treated with i.v. paclitaxel 250 mg/m2 over 3 h every 21 days. They received standard premedications and granulocyte colony stimulating factor (G-CSF) support (5 μg/kg/day). Median (range) age was 49 (29-81) years and performance status Zubrod was 1 (0-2). One patient had a complete response and seven patients had a partial response (25%, 95% CI 8-38%). The median survival was 7.3 months. Granulocytopenia was brief and non-cumulative. G-CSF was used for a median (range) of 8 (1-15) days per cycle. In conclusion: paclitaxel is active in patients with squamous cell cancer of the cervix and is well tolerated in this dose schedule with G-CSF support.
Original language | English (US) |
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Pages (from-to) | 657-661 |
Number of pages | 5 |
Journal | Anti-Cancer Drugs |
Volume | 8 |
Issue number | 7 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
Keywords
- Cervix cancer
- Granulocyte colony stimulating factor
- Paclitaxel
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Pharmacology (medical)
- Cancer Research