An x-ray image guidance system for small animal stereotactic irradiation

K. H. Song, R. Pidikiti, S. Stojadinovic, M. Speiser, S. Seliounine, D. Saha, T. D. Solberg

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

An x-ray image-guided small animal stereotactic irradiator was developed and characterized to enable tumor visualization and accurate target localization for small field, high dose irradiation. The system utilizes a custom collimation system, a motorized positioning system (x, y, θ), a digital imaging panel and operating software, and is integrated with a commercial x-ray unit. The essential characteristics of the irradiator include small radiation fields (1-10 mm), high dose rate (> 10 Gy min-1) and submillimeter target localization. The software enables computer-controlled image acquisition, stage motion and target localization providing simple and precise automated target localization. The imaging panel was characterized in terms of signal-tonoise ratio (SNR), contrast-to-noise ratio (CNR) and spatial resolution. Overall localization accuracy and precision were assessed. SNR, CNR and spatial resolution are 24 dB, 21 dB and 2.8 lp mm-1, respectively, and localization accuracy is approximately 65 μm with 6 μm precision. With the aid of image guidance, system performance was subsequently used to evaluate radiation response in a rat orthotopic lung tumor effectively sparing normal tissues and in a mouse normal lung. The capabilities of 3D treatment and cone-beam computed tomography are presented for 3D localization and delivery as a work in progress.

Original languageEnglish (US)
Pages (from-to)7345-7362
Number of pages18
JournalPhysics in medicine and biology
Volume55
Issue number23
DOIs
StatePublished - Dec 7 2010

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ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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