Anabolic androgenic steroids and intracellular calcium signaling: A mini review on mechanisms and physiological implications

J. M. Vicencio, M. Estrada, D. Galvis, R. Bravo, A. E. Contreras, D. Rotter, G. Szabadkai, Joseph A Hill, Beverly A Rothermel, E. Jaimovich, S. Lavandero

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Increasing evidence suggests that nongenomic effects of testosterone and anabolic androgenic steroids (AAS) operate concertedly with genomic effects. Classically, these responses have been viewed as separate and independent processes, primarily because nongenomic responses are faster and appear to be mediated by membrane androgen receptors, whereas long-term genomic effects are mediated through cytosolic androgen receptors regulating transcriptional activity. Numerous studies have demonstrated increases in intracellular Ca2+ in response to AAS. These Ca2+ mediated responses have been seen in a diversity of cell types, including osteoblasts, platelets, skeletal muscle cells, cardiac myocytes and neurons. The versatility of Ca2+ as a second messenger provides these responses with a vast number of pathophysiological implications. In cardiac cells, testosterone elicits voltage-dependent Ca2+ oscillations and IP3Rmediated Ca2+ release from internal stores, leading to activation of MAPK and mTOR signaling that promotes cardiac hypertrophy. In neurons, depending upon concentration, testosterone can provoke either physiological Ca2+ oscillations, essential for synaptic plasticity, or sustained, pathological Ca2+ transients that lead to neuronal apoptosis. We propose therefore, that Ca2+ acts as an important point of crosstalk between nongenomic and genomic AAS signaling, representing a central regulator that bridges these previously thought to be divergent responses.

Original languageEnglish (US)
Pages (from-to)390-398
Number of pages9
JournalMini-Reviews in Medicinal Chemistry
Volume11
Issue number5
DOIs
StatePublished - Jun 2011

Fingerprint

Testosterone Congeners
Calcium Signaling
Testosterone
Androgen Receptors
Neurons
Neuronal Plasticity
Cardiomegaly
Second Messenger Systems
Osteoblasts
Cardiac Myocytes
Muscle Cells
Skeletal Muscle
Blood Platelets
Apoptosis
Membranes

Keywords

  • Androgens
  • Ca
  • Cardiac myocytes
  • Genomic
  • Heart
  • Neurons
  • Nongenomic
  • Skeletal muscle cells
  • Testosterone

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Anabolic androgenic steroids and intracellular calcium signaling : A mini review on mechanisms and physiological implications. / Vicencio, J. M.; Estrada, M.; Galvis, D.; Bravo, R.; Contreras, A. E.; Rotter, D.; Szabadkai, G.; Hill, Joseph A; Rothermel, Beverly A; Jaimovich, E.; Lavandero, S.

In: Mini-Reviews in Medicinal Chemistry, Vol. 11, No. 5, 06.2011, p. 390-398.

Research output: Contribution to journalArticle

Vicencio, JM, Estrada, M, Galvis, D, Bravo, R, Contreras, AE, Rotter, D, Szabadkai, G, Hill, JA, Rothermel, BA, Jaimovich, E & Lavandero, S 2011, 'Anabolic androgenic steroids and intracellular calcium signaling: A mini review on mechanisms and physiological implications', Mini-Reviews in Medicinal Chemistry, vol. 11, no. 5, pp. 390-398. https://doi.org/10.2174/138955711795445880
Vicencio, J. M. ; Estrada, M. ; Galvis, D. ; Bravo, R. ; Contreras, A. E. ; Rotter, D. ; Szabadkai, G. ; Hill, Joseph A ; Rothermel, Beverly A ; Jaimovich, E. ; Lavandero, S. / Anabolic androgenic steroids and intracellular calcium signaling : A mini review on mechanisms and physiological implications. In: Mini-Reviews in Medicinal Chemistry. 2011 ; Vol. 11, No. 5. pp. 390-398.
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