Anabolic effects of fluoride on bone

Charles Y C Pak, Joseph E. Zerwekh, Peter Antich

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Fluoride exerts a biphasic action at the level of osteoblasts, on bone mineral, on bone structure and function, and in the treatment of osteoporosis. At low circulating concentrations, skeletal uptake of fluoride is limited and the effects are beneficial. At higher concentrations and greater skeletal uptake, fluoride may cause the formation of abnormally mineralized bone of impaired quality. A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume6
Issue number7
DOIs
StatePublished - 1995

Fingerprint

Anabolic Agents
Fluorides
Bone and Bones
Calcium Citrate
Sodium Fluoride
Postmenopausal Osteoporosis
Poisons
Osteoblasts
Osteoporosis
Minerals

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Anabolic effects of fluoride on bone. / Pak, Charles Y C; Zerwekh, Joseph E.; Antich, Peter.

In: Trends in Endocrinology and Metabolism, Vol. 6, No. 7, 1995, p. 229-234.

Research output: Contribution to journalArticle

Pak, Charles Y C ; Zerwekh, Joseph E. ; Antich, Peter. / Anabolic effects of fluoride on bone. In: Trends in Endocrinology and Metabolism. 1995 ; Vol. 6, No. 7. pp. 229-234.
@article{7b094a7309e64d369815327182a67a3c,
title = "Anabolic effects of fluoride on bone",
abstract = "Fluoride exerts a biphasic action at the level of osteoblasts, on bone mineral, on bone structure and function, and in the treatment of osteoporosis. At low circulating concentrations, skeletal uptake of fluoride is limited and the effects are beneficial. At higher concentrations and greater skeletal uptake, fluoride may cause the formation of abnormally mineralized bone of impaired quality. A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.",
author = "Pak, {Charles Y C} and Zerwekh, {Joseph E.} and Peter Antich",
year = "1995",
doi = "10.1016/1043-2760(95)00111-T",
language = "English (US)",
volume = "6",
pages = "229--234",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Anabolic effects of fluoride on bone

AU - Pak, Charles Y C

AU - Zerwekh, Joseph E.

AU - Antich, Peter

PY - 1995

Y1 - 1995

N2 - Fluoride exerts a biphasic action at the level of osteoblasts, on bone mineral, on bone structure and function, and in the treatment of osteoporosis. At low circulating concentrations, skeletal uptake of fluoride is limited and the effects are beneficial. At higher concentrations and greater skeletal uptake, fluoride may cause the formation of abnormally mineralized bone of impaired quality. A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.

AB - Fluoride exerts a biphasic action at the level of osteoblasts, on bone mineral, on bone structure and function, and in the treatment of osteoporosis. At low circulating concentrations, skeletal uptake of fluoride is limited and the effects are beneficial. At higher concentrations and greater skeletal uptake, fluoride may cause the formation of abnormally mineralized bone of impaired quality. A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.

UR - http://www.scopus.com/inward/record.url?scp=0029074780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029074780&partnerID=8YFLogxK

U2 - 10.1016/1043-2760(95)00111-T

DO - 10.1016/1043-2760(95)00111-T

M3 - Article

C2 - 11540313

AN - SCOPUS:0029074780

VL - 6

SP - 229

EP - 234

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 7

ER -