Anabolic effects of insulin-like growth factor in combination with insulin-like growth factor binding protein-3 in severely burned adults

Meele A. Debroy, Steven E. Wolf, Xiao Jun Zhang, David L. Chinkes, Arny A. Ferrando, Robert R. Wolfe, David N. Herndon

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Background: The purpose of this study was to determine the anabolic effects of recombinant human insulin-like growth factor-I (rhIGF-1) complexed with its principal binding protein IGF-1 binding protein-3 (IGFBP-3) in severely burned adults. Methods: Ten burned adults were studied consecutively after receiving saline (pretreatment), then rhIGF-1/IGFBP-3 (treatment) for 5 days. Doses were 1, 2, and 4 mg/kg per day. Glucose, electrolytes, hormones, and leg muscle protein metabolism were determined. Nine other studies were performed on similarly injured adults at comparable times to the treatment studies to control for time effects. Results: Serum IGF-1 and IGFBP-3 levels increased with all doses, but no incremental increases were found. Leg protein balance improved with rhIGF-1/IGFBP-3, which was associated with an increase in muscle protein fractional synthetic rate. These effects were independent of time. All patients were euglycemic without electrolyte imbalances. Conclusion: Net protein synthesis in the isolated leg of severely burned adults improved with rhIGF-1/IGFBP-3 without development of glucose abnormalities.

Original languageEnglish (US)
Pages (from-to)904-911
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume47
Issue number5
DOIs
StatePublished - Nov 1999

Keywords

  • Anabolic hormones
  • Burns
  • Protein balance
  • RhIGF-1/IGFBP-3

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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