Anaesthetic and forebrain modulation of raphe-coerulean interactions

A. McRae-Degueurce, C. M. Sinton

Research output: Contribution to journalArticle


Variations in tyrosine hydroxylase (TH) activity and serotonin (5-HT) content in the rat locus coeruleus were measured four days after lesion of the nucleus raphe centralis superior. Lesions were made under either ether or pentobarbital anaesthesia and, in addition, (under ether) in rats pretreated with atropine or with lesions of the medial septum. Results showed a dissociation between 5-HT reduction and TH induction, differences due to the anaesthetic used, and a possible influence from limbic centres on 5-HT in the LC. These findings are discussed in terms of the apparent complexity of raphe-coerulean interactions.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalExperimental Brain Research
Issue number2
StatePublished - Mar 1 1984



  • Diethyl ether
  • Locus coeruleus
  • Raphe centralis
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

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