Analysis of antibody production induced by allogeneic tumor cells inoculated into the anterior chamber of the eye

J. Y. Niederkorn, J. W. Streilein

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Abstract

Humoral immune responses to alloantigens on P815 mastocytoma cells placed into the anterior chamber of murine eyes were studied. The results show that: (1) the amount of specific serum antibody produced by recipients of intracamerally injected P815 cells is directly proportional to the degree of immunogenetic disparity between the recipient and the injected cells; (2) destruction of allogeneic intraocular tumors is mediated, at least in part, by specific antibodies; and (3) retention of allogeneic tissue within the anterior chamber for 3 to 4 days after inoculation is essential to the elicitation of specific antibody formation. We conclude that alloantigens introduced into the anterior chamber are presented to the systemic immune apparatus in a very unique manner resulting in the preferential stimulation of specific antibody production without awakening specific cell-mediated immunity.

Original languageEnglish (US)
Pages (from-to)573-577
Number of pages5
JournalTransplantation
Volume33
Issue number6
DOIs
StatePublished - Jun 1982

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ASJC Scopus subject areas

  • Transplantation

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