TY - BOOK
T1 - Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos
AU - Verduzco, Daniel
AU - Amatruda, James F.
PY - 2011
Y1 - 2011
N2 - Proper control of cell proliferation is critical for normal development, growth, differentiation, and tissue homeostasis. Dysregulation of cell division and cell death underlies almost all cancers, and contributes to the pathology of birth defects and degenerative diseases. The zebrafish has proved to be an excellent system for elucidating the roles of the cell cycle in normal development, and ways in which dysregulation of cell proliferation contributes to disease. This chapter describes the methods for studying the cell cycle in zebrafish embryos, including protocols to examine cell proliferation, DNA damage, senescence, and cell death.
AB - Proper control of cell proliferation is critical for normal development, growth, differentiation, and tissue homeostasis. Dysregulation of cell division and cell death underlies almost all cancers, and contributes to the pathology of birth defects and degenerative diseases. The zebrafish has proved to be an excellent system for elucidating the roles of the cell cycle in normal development, and ways in which dysregulation of cell proliferation contributes to disease. This chapter describes the methods for studying the cell cycle in zebrafish embryos, including protocols to examine cell proliferation, DNA damage, senescence, and cell death.
KW - Cell death
KW - Cell proliferation
KW - Differentiation
KW - Dysregulation
KW - Forward-genetic screen
KW - Senescence
UR - http://www.scopus.com/inward/record.url?scp=79955600598&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955600598&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-387036-0.00002-5
DO - 10.1016/B978-0-12-387036-0.00002-5
M3 - Book
C2 - 21550438
AN - SCOPUS:79955600598
VL - 101
T3 - Methods in Cell Biology
BT - Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos
PB - Unknown Publisher
ER -