Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos

Daniel Verduzco, James F. Amatruda

Research output: Book/ReportBook

28 Citations (Scopus)

Abstract

Proper control of cell proliferation is critical for normal development, growth, differentiation, and tissue homeostasis. Dysregulation of cell division and cell death underlies almost all cancers, and contributes to the pathology of birth defects and degenerative diseases. The zebrafish has proved to be an excellent system for elucidating the roles of the cell cycle in normal development, and ways in which dysregulation of cell proliferation contributes to disease. This chapter describes the methods for studying the cell cycle in zebrafish embryos, including protocols to examine cell proliferation, DNA damage, senescence, and cell death.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages20
Volume101
DOIs
StatePublished - 2011

Publication series

NameMethods in Cell Biology
Volume101
ISSN (Print)0091679X

Fingerprint

Cell Aging
Zebrafish
Cell Death
Embryonic Structures
Cell Proliferation
Cell Cycle
Growth and Development
Cell Division
DNA Damage
Homeostasis
Pathology
Neoplasms

Keywords

  • Cell death
  • Cell proliferation
  • Differentiation
  • Dysregulation
  • Forward-genetic screen
  • Senescence

ASJC Scopus subject areas

  • Cell Biology

Cite this

Verduzco, D., & Amatruda, J. F. (2011). Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos. (Methods in Cell Biology; Vol. 101). Unknown Publisher. https://doi.org/10.1016/B978-0-12-387036-0.00002-5

Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos. / Verduzco, Daniel; Amatruda, James F.

Unknown Publisher, 2011. 20 p. (Methods in Cell Biology; Vol. 101).

Research output: Book/ReportBook

Verduzco, D & Amatruda, JF 2011, Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos. Methods in Cell Biology, vol. 101, vol. 101, Unknown Publisher. https://doi.org/10.1016/B978-0-12-387036-0.00002-5
Verduzco, Daniel ; Amatruda, James F. / Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos. Unknown Publisher, 2011. 20 p. (Methods in Cell Biology).
@book{3a37f7ad627648e8a9f131535e63cc14,
title = "Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos",
abstract = "Proper control of cell proliferation is critical for normal development, growth, differentiation, and tissue homeostasis. Dysregulation of cell division and cell death underlies almost all cancers, and contributes to the pathology of birth defects and degenerative diseases. The zebrafish has proved to be an excellent system for elucidating the roles of the cell cycle in normal development, and ways in which dysregulation of cell proliferation contributes to disease. This chapter describes the methods for studying the cell cycle in zebrafish embryos, including protocols to examine cell proliferation, DNA damage, senescence, and cell death.",
keywords = "Cell death, Cell proliferation, Differentiation, Dysregulation, Forward-genetic screen, Senescence",
author = "Daniel Verduzco and Amatruda, {James F.}",
year = "2011",
doi = "10.1016/B978-0-12-387036-0.00002-5",
language = "English (US)",
volume = "101",
series = "Methods in Cell Biology",
publisher = "Unknown Publisher",

}

TY - BOOK

T1 - Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos

AU - Verduzco, Daniel

AU - Amatruda, James F.

PY - 2011

Y1 - 2011

N2 - Proper control of cell proliferation is critical for normal development, growth, differentiation, and tissue homeostasis. Dysregulation of cell division and cell death underlies almost all cancers, and contributes to the pathology of birth defects and degenerative diseases. The zebrafish has proved to be an excellent system for elucidating the roles of the cell cycle in normal development, and ways in which dysregulation of cell proliferation contributes to disease. This chapter describes the methods for studying the cell cycle in zebrafish embryos, including protocols to examine cell proliferation, DNA damage, senescence, and cell death.

AB - Proper control of cell proliferation is critical for normal development, growth, differentiation, and tissue homeostasis. Dysregulation of cell division and cell death underlies almost all cancers, and contributes to the pathology of birth defects and degenerative diseases. The zebrafish has proved to be an excellent system for elucidating the roles of the cell cycle in normal development, and ways in which dysregulation of cell proliferation contributes to disease. This chapter describes the methods for studying the cell cycle in zebrafish embryos, including protocols to examine cell proliferation, DNA damage, senescence, and cell death.

KW - Cell death

KW - Cell proliferation

KW - Differentiation

KW - Dysregulation

KW - Forward-genetic screen

KW - Senescence

UR - http://www.scopus.com/inward/record.url?scp=79955600598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955600598&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-387036-0.00002-5

DO - 10.1016/B978-0-12-387036-0.00002-5

M3 - Book

C2 - 21550438

AN - SCOPUS:79955600598

VL - 101

T3 - Methods in Cell Biology

BT - Analysis of Cell Proliferation, Senescence, and Cell Death in Zebrafish Embryos

PB - Unknown Publisher

ER -