Abstract
The region of yeast chromosome III between the HIS4 and LEU2 genes has an unusually high frequency of meiotic recombination. In order to determine the pattern of cross-over and gene conversion events, we constructed a strain with a number of heterozygous markers in this 25-kb interval. We found that very high levels of reombination are localized to regions of DNA near HIS4. In addition, analysis of the patterns of co-conversion of adjacent markers suggests that there is more than one initiation site contributing to recombination of HIS4.
Original language | English (US) |
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Pages (from-to) | 21-30 |
Number of pages | 10 |
Journal | Current Genetics |
Volume | 26 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1994 |
Keywords
- Cross-over
- Gene conversion
- Recombination
- Yeast
ASJC Scopus subject areas
- Genetics