Analysis of meiotic recombination events near a recombination hotspot in the yeast Saccharomyces cerevisiae

Michael A. White, Thomas D. Petes

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The region of yeast chromosome III between the HIS4 and LEU2 genes has an unusually high frequency of meiotic recombination. In order to determine the pattern of cross-over and gene conversion events, we constructed a strain with a number of heterozygous markers in this 25-kb interval. We found that very high levels of reombination are localized to regions of DNA near HIS4. In addition, analysis of the patterns of co-conversion of adjacent markers suggests that there is more than one initiation site contributing to recombination of HIS4.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalCurrent Genetics
Volume26
Issue number1
DOIs
StatePublished - Jul 1994

Keywords

  • Cross-over
  • Gene conversion
  • Recombination
  • Yeast

ASJC Scopus subject areas

  • Genetics

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