Analysis of [11C]Choline and [13N]Ammonia using a single HPIC method

Huailei Jiang; Ping Fang; Mark S. Jacobson; Manoj K. Jain; Hancheng Cai

doi:10.1016/j.apradiso.2020.109560

Analysis of [¹¹C]Choline and [¹³N]Ammonia using a single HPIC method

Huailei Jiang, Ping Fang, Mark S. Jacobson, Manoj K. Jain, Hancheng Cai

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A single HPIC method was developed and validated for the analysis of both [¹¹C]Choline and [¹³N]Ammonia with the same setup. The HPIC system suitability tests were performed and [¹¹C]Choline and [¹³N]Ammonia were used to verify their performance on this HPIC method. The HPIC setup and method provides qualitative and quantitative analysis information of [¹¹C]Choline and [¹³N]Ammonia. The data suggested this HPIC method is validated for determining radiochemical/chemical purity and radiochemical identity of [¹¹C]Choline and [¹³N]Ammonia products in CGMP compliant manufacturing process.

Original language	English (US)
Article number	109560
Journal	Applied Radiation and Isotopes
Volume	168
DOIs	https://doi.org/10.1016/j.apradiso.2020.109560
State	Published - Feb 2021
Externally published	Yes

Keywords

HPIC
Method validation
PET
Quality control
[C]Choline
[N]Ammonia

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2020.109560

Cite this

@article{1edf2836583747e39842a6b47982e17e,

title = "Analysis of [11C]Choline and [13N]Ammonia using a single HPIC method",

abstract = "A single HPIC method was developed and validated for the analysis of both [11C]Choline and [13N]Ammonia with the same setup. The HPIC system suitability tests were performed and [11C]Choline and [13N]Ammonia were used to verify their performance on this HPIC method. The HPIC setup and method provides qualitative and quantitative analysis information of [11C]Choline and [13N]Ammonia. The data suggested this HPIC method is validated for determining radiochemical/chemical purity and radiochemical identity of [11C]Choline and [13N]Ammonia products in CGMP compliant manufacturing process.",

keywords = "HPIC, Method validation, PET, Quality control, [C]Choline, [N]Ammonia",

author = "Huailei Jiang and Ping Fang and Jacobson, {Mark S.} and Jain, {Manoj K.} and Hancheng Cai",

note = "Funding Information: This work was financially supported by department of radiology, Mayo Clinic , Jacksonville FL. We thank Jeffrey T. Snyder, Raymond A. Steichen and Jason R. Ellinghuysen for their contribution on C-11 and N-13 targetry, and Jeremiah E. Alicea for [ 13 N]Ammonia production. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2021",

month = feb,

doi = "10.1016/j.apradiso.2020.109560",

language = "English (US)",

volume = "168",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

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AU - Jiang, Huailei

AU - Fang, Ping

AU - Jacobson, Mark S.

AU - Jain, Manoj K.

AU - Cai, Hancheng

N1 - Funding Information: This work was financially supported by department of radiology, Mayo Clinic , Jacksonville FL. We thank Jeffrey T. Snyder, Raymond A. Steichen and Jason R. Ellinghuysen for their contribution on C-11 and N-13 targetry, and Jeremiah E. Alicea for [ 13 N]Ammonia production. Publisher Copyright: © 2020 Elsevier Ltd

PY - 2021/2

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N2 - A single HPIC method was developed and validated for the analysis of both [11C]Choline and [13N]Ammonia with the same setup. The HPIC system suitability tests were performed and [11C]Choline and [13N]Ammonia were used to verify their performance on this HPIC method. The HPIC setup and method provides qualitative and quantitative analysis information of [11C]Choline and [13N]Ammonia. The data suggested this HPIC method is validated for determining radiochemical/chemical purity and radiochemical identity of [11C]Choline and [13N]Ammonia products in CGMP compliant manufacturing process.

AB - A single HPIC method was developed and validated for the analysis of both [11C]Choline and [13N]Ammonia with the same setup. The HPIC system suitability tests were performed and [11C]Choline and [13N]Ammonia were used to verify their performance on this HPIC method. The HPIC setup and method provides qualitative and quantitative analysis information of [11C]Choline and [13N]Ammonia. The data suggested this HPIC method is validated for determining radiochemical/chemical purity and radiochemical identity of [11C]Choline and [13N]Ammonia products in CGMP compliant manufacturing process.

KW - HPIC

KW - Method validation

KW - PET

KW - Quality control

KW - [C]Choline

KW - [N]Ammonia

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