Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

N. Brindle, Y. Song, E. Rogaeva, S. Premkumar, G. Levesque, G. Yu, M. Ikeda, M. Nishimura, A. Paterson, S. Sorbi, R. Duara, L. Farrer, P. St George-Hyslop

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Abstract

The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.

Original languageEnglish (US)
Pages (from-to)933-935
Number of pages3
JournalHuman Molecular Genetics
Volume7
Issue number5
DOIs
StatePublished - May 1998

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Butyrylcholinesterase
Chromosomes, Human, Pair 3
Genetic Markers
Alzheimer Disease
Genes
Alleles
Apolipoprotein E4

ASJC Scopus subject areas

  • Genetics

Cite this

Brindle, N., Song, Y., Rogaeva, E., Premkumar, S., Levesque, G., Yu, G., ... St George-Hyslop, P. (1998). Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease. Human Molecular Genetics, 7(5), 933-935. https://doi.org/10.1093/hmg/7.5.933

Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease. / Brindle, N.; Song, Y.; Rogaeva, E.; Premkumar, S.; Levesque, G.; Yu, G.; Ikeda, M.; Nishimura, M.; Paterson, A.; Sorbi, S.; Duara, R.; Farrer, L.; St George-Hyslop, P.

In: Human Molecular Genetics, Vol. 7, No. 5, 05.1998, p. 933-935.

Research output: Contribution to journalArticle

Brindle, N, Song, Y, Rogaeva, E, Premkumar, S, Levesque, G, Yu, G, Ikeda, M, Nishimura, M, Paterson, A, Sorbi, S, Duara, R, Farrer, L & St George-Hyslop, P 1998, 'Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease', Human Molecular Genetics, vol. 7, no. 5, pp. 933-935. https://doi.org/10.1093/hmg/7.5.933
Brindle, N. ; Song, Y. ; Rogaeva, E. ; Premkumar, S. ; Levesque, G. ; Yu, G. ; Ikeda, M. ; Nishimura, M. ; Paterson, A. ; Sorbi, S. ; Duara, R. ; Farrer, L. ; St George-Hyslop, P. / Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease. In: Human Molecular Genetics. 1998 ; Vol. 7, No. 5. pp. 933-935.
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