Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation

C. A. Elmets, P. R. Bergstresser, R. E. Tigelaar, P. J. Wood, J. W. Streilein

Research output: Contribution to journalArticle

289 Citations (Scopus)

Abstract

Acute, low dose ultraviolet B radiation of murine body wall skin followed by local application of DNFB produces a state of antigen-specific unresponsiveness. This state is maintained at least in part by an Lyt-1+ T cell that effects unresponsiveness by impairing the induction phase of contact hypersensitivity. The absence of suppressor cells capable of acting at the effector stage of immunity suggests that tolerogenic signals derived from the skin establish suppressor networks that are incomplete and perhaps different from networks that are induced by systemic administration of tolerogens. It is proposed that ultraviolet radiation produces its effects by impairing the antigen-presenting potential of resident Langerhans cells in whose absence hapten-derivatized keratinocytes (or their products) are able to deliver a tolerogenic signal.

Original languageEnglish (US)
Pages (from-to)781-794
Number of pages14
JournalJournal of Experimental Medicine
Volume158
Issue number3
StatePublished - 1983

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Haptens
Dinitrofluorobenzene
Radiation
Antigens
Skin
Langerhans Cells
Contact Dermatitis
Keratinocytes
Immunity
T-Lymphocytes
Tolerogen

ASJC Scopus subject areas

  • Immunology

Cite this

Elmets, C. A., Bergstresser, P. R., Tigelaar, R. E., Wood, P. J., & Streilein, J. W. (1983). Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. Journal of Experimental Medicine, 158(3), 781-794.

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. / Elmets, C. A.; Bergstresser, P. R.; Tigelaar, R. E.; Wood, P. J.; Streilein, J. W.

In: Journal of Experimental Medicine, Vol. 158, No. 3, 1983, p. 781-794.

Research output: Contribution to journalArticle

Elmets, CA, Bergstresser, PR, Tigelaar, RE, Wood, PJ & Streilein, JW 1983, 'Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation', Journal of Experimental Medicine, vol. 158, no. 3, pp. 781-794.
Elmets, C. A. ; Bergstresser, P. R. ; Tigelaar, R. E. ; Wood, P. J. ; Streilein, J. W. / Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. In: Journal of Experimental Medicine. 1983 ; Vol. 158, No. 3. pp. 781-794.
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