Analyzing the molecular foundations of commensalism in the mouse intestine

Lora V. Hooper, Per G. Falk, Jeffrey I. Gordon

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

We maintain complex societies of nonpathogenic microbes on our mucosal surfaces. Although the stability of this flora is important for human health, very little is known about how its constituents communicate with us to forge stable and mutually advantageous relationships. The vast majority of these indigenous microbes reside in the intestine. Recent studies of a gut commensal, Bacteroides thetaiotaomicron, has revealed a novel signaling pathway that allows the microbe and host to actively collaborate to produce a nutrient foundation that can be used by this bacterium. This pathway illustrates the type of dynamic molecular interactions that help define commensal relationships.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalCurrent Opinion in Microbiology
Volume3
Issue number1
DOIs
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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